{"title":"Maternal Alcohol Consumption and Risk of Childhood Cancers: A Systematic Review and Meta-Analysis.","authors":"Roya Rashti, Faezeh Ghaaseemi, Jalal Poorolajal","doi":"10.31557/APJCP.2025.26.2.361","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Childhood cancers are a leading cause of death among children worldwide. Maternal alcohol consumption before and during pregnancy has been suggested as a potential risk factor for childhood cancers. However, the evidence to support this association is inconsistent. A systematic review and meta-analysis were conducted to clarify this association.</p><p><strong>Methods: </strong>We performed a systematic search of PubMed, Web of Science, and Scopus databases until May 2023 to identify observational studies reporting associations between maternal alcohol consumption and childhood cancers. Heterogeneity between studies was evaluated using the χ2, τ2, and I2 statistics. Publication bias was assessed using Begg and Egger tests. We calculated the odds ratio (OR) with a 95% confidence interval (CI) using a random-effects model.</p><p><strong>Results: </strong>Out of 18,583 studies retrieved from the search, 31 studies involving 47,277 participants met the eligibility criteria. Our meta-analysis found that maternal alcohol consumption before and during pregnancy was associated with an increased risk of childhood cancers with OR of 1.15 (95% CI: 1.00, 1.33) and 1.11 (95% CI: 1.03, 1.20), respectively.</p><p><strong>Conclusions: </strong>Our meta-analysis found evidence of a positive association between maternal alcohol consumption before and during pregnancy and the risk of childhood cancers. These findings suggest a need for public health interventions aimed at reducing alcohol consumption during pregnancy to potentially prevent childhood cancers.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 2","pages":"361-369"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Cancer Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31557/APJCP.2025.26.2.361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Childhood cancers are a leading cause of death among children worldwide. Maternal alcohol consumption before and during pregnancy has been suggested as a potential risk factor for childhood cancers. However, the evidence to support this association is inconsistent. A systematic review and meta-analysis were conducted to clarify this association.
Methods: We performed a systematic search of PubMed, Web of Science, and Scopus databases until May 2023 to identify observational studies reporting associations between maternal alcohol consumption and childhood cancers. Heterogeneity between studies was evaluated using the χ2, τ2, and I2 statistics. Publication bias was assessed using Begg and Egger tests. We calculated the odds ratio (OR) with a 95% confidence interval (CI) using a random-effects model.
Results: Out of 18,583 studies retrieved from the search, 31 studies involving 47,277 participants met the eligibility criteria. Our meta-analysis found that maternal alcohol consumption before and during pregnancy was associated with an increased risk of childhood cancers with OR of 1.15 (95% CI: 1.00, 1.33) and 1.11 (95% CI: 1.03, 1.20), respectively.
Conclusions: Our meta-analysis found evidence of a positive association between maternal alcohol consumption before and during pregnancy and the risk of childhood cancers. These findings suggest a need for public health interventions aimed at reducing alcohol consumption during pregnancy to potentially prevent childhood cancers.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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