Nongestational Ovarian Choriocarcinoma with Precocious Puberty in a 7-Year-Old Girl: A Rare Case Report.

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of pediatric and adolescent gynecology Pub Date : 2025-02-26 DOI:10.1016/j.jpag.2025.02.007

Kako Ono, Reina Hoshi, Takayuki Hirano, Yosuke Watanabe, Shumpei Goto, Takashi Hosokawa, Shuichiro Uehara

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引用次数: 0

Abstract

Background: Nongestational ovarian choriocarcinoma (NGOC) is extremely rare, particularly in the pediatric population. Few case reports have discussed NGOC with precocious puberty and mentioned both tumor markers (β-human chorionic gonadotropin [hCG], alpha-fetoprotein, CA125) and the dynamics of gonadotropic and gonadal hormones.

Case: A 7-year-old girl presented with early puberty and an abdominal mass. Laboratory tests revealed elevated estradiol, β-hCG, and CA125 levels, with suppressed luteinizing hormone and follicle-stimulating hormone. She was diagnosed with ovarian choriocarcinoma and precocious puberty. Following tumor resection, her hormone levels normalized, and symptoms resolved.

Conclusion: Pediatric ovarian choriocarcinomas are rare and may present with precocious puberty. Comprehensive endocrine evaluation, including serum hormone assays, is essential for diagnosis. Hormonal profiles in pediatric patients may differ from those in adults, with estradiol levels often being markedly elevated compared to age-specific reference ranges, and progesterone levels being relatively low.

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7岁女童非妊娠期卵巢绒毛膜癌伴性早熟1例罕见病例报告及文献复习。

背景：非妊娠期卵巢绒毛膜癌（NGOC）极为罕见，特别是在儿科人群中。很少有病例报告讨论NGOC与性早熟，并提到肿瘤标志物（β-hCG， AFP, CA125）和促性腺激素和性腺激素的动态。病例：一名7岁女童，表现为青春期提前及腹部肿块。实验室检测显示雌二醇、β-hCG和CA125水平升高，促黄体生成素和促卵泡刺激素抑制。她被诊断患有卵巢绒毛膜癌和性早熟。肿瘤切除后，她的激素水平恢复正常，症状缓解。结论：小儿卵巢绒毛膜癌是罕见的，可能表现为性早熟。全面的内分泌评估，包括血清激素测定，对诊断是必不可少的。儿童患者的激素谱可能与成人不同，与特定年龄的参考范围相比，雌二醇水平通常显著升高，而孕酮水平相对较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pediatric and adolescent gynecology 医学-妇产科学

CiteScore

3.90

自引率

11.10%

发文量

251

审稿时长

57 days

期刊介绍： Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.