Shingles in HIV: Outcome and discovery.

IF 1.4 4区 医学 Q4 IMMUNOLOGY
International Journal of STD & AIDS Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI:10.1177/09564624251324975
Mouna Guechchati, Meryem Soughi, Samira Rabhi, Hamza Idrissi Janati, Zakia Douhi, Sara Elloudi, Hanane Baybay, Fatima Zahra Mernissi
{"title":"Shingles in HIV: Outcome and discovery.","authors":"Mouna Guechchati, Meryem Soughi, Samira Rabhi, Hamza Idrissi Janati, Zakia Douhi, Sara Elloudi, Hanane Baybay, Fatima Zahra Mernissi","doi":"10.1177/09564624251324975","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Herpes zoster (HZ) is a frequent manifestation in people living with HIV (PLHIV), with a significantly higher incidence compared to the general population. It often presents as an early indicator of immunosuppression, making timely diagnosis and treatment crucial. <b>Methods:</b> This retrospective study, conducted from January 2015 to September 2024, analyzed 45 PLHIV diagnosed with HZ. Patients were recruited from the Infectious Diseases Department (for HIV-related HZ cases) and the Dermatology Department (for complicated HZ cases requiring hospitalization). Clinical and demographic data were collected, including ART status, HZ presentation, and treatment outcomes. <b>Results:</b> The mean patient age was 36.35 years, with a male predominance (M/F ratio: 8). Among the cohort, 12 patients had undiagnosed HIV, and HZ was the presenting symptom that led to HIV diagnosis. The thoracic metameric variant was the most common, with erythematous-vesicular, necrotic-hemorrhagic, and bullous forms observed. 21 patients were on antiretroviral therapy (ART), six of whom developed HZ shortly after ART initiation. Treatment involved oral or intravenous acyclovir, with hospitalization required for complicated or multi-metameric forms and high-risk patients. Outpatient management with close monitoring was provided for stable cases. <b>Conclusions:</b> HZ remains a significant opportunistic infection in PLHIV, often serving as a sentinel sign of undiagnosed HIV. Early HIV screening in patients presenting with HZ and timely initiation of antiviral therapy are essential for improved outcomes. Enhanced awareness and integrated HIV-HZ management strategies are crucial in clinical practice.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"506-509"},"PeriodicalIF":1.4000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of STD & AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09564624251324975","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Herpes zoster (HZ) is a frequent manifestation in people living with HIV (PLHIV), with a significantly higher incidence compared to the general population. It often presents as an early indicator of immunosuppression, making timely diagnosis and treatment crucial. Methods: This retrospective study, conducted from January 2015 to September 2024, analyzed 45 PLHIV diagnosed with HZ. Patients were recruited from the Infectious Diseases Department (for HIV-related HZ cases) and the Dermatology Department (for complicated HZ cases requiring hospitalization). Clinical and demographic data were collected, including ART status, HZ presentation, and treatment outcomes. Results: The mean patient age was 36.35 years, with a male predominance (M/F ratio: 8). Among the cohort, 12 patients had undiagnosed HIV, and HZ was the presenting symptom that led to HIV diagnosis. The thoracic metameric variant was the most common, with erythematous-vesicular, necrotic-hemorrhagic, and bullous forms observed. 21 patients were on antiretroviral therapy (ART), six of whom developed HZ shortly after ART initiation. Treatment involved oral or intravenous acyclovir, with hospitalization required for complicated or multi-metameric forms and high-risk patients. Outpatient management with close monitoring was provided for stable cases. Conclusions: HZ remains a significant opportunistic infection in PLHIV, often serving as a sentinel sign of undiagnosed HIV. Early HIV screening in patients presenting with HZ and timely initiation of antiviral therapy are essential for improved outcomes. Enhanced awareness and integrated HIV-HZ management strategies are crucial in clinical practice.

HIV带状疱疹:结果和发现。
背景:带状疱疹(HZ)是HIV感染者(PLHIV)的一种常见表现,其发病率明显高于一般人群。它通常是免疫抑制的早期指标,因此及时诊断和治疗至关重要。方法:本回顾性研究于2015年1月至2024年9月进行,分析了45例诊断为HZ的PLHIV。患者从传染病科(hiv相关HZ病例)和皮肤科(需要住院治疗的复杂HZ病例)招募。收集临床和人口统计数据,包括ART状态、HZ表现和治疗结果。结果:患者平均年龄36.35岁,男性居多(M/F比:8)。队列中有12例患者未确诊HIV, HZ是导致HIV诊断的首发症状。胸椎变异体最常见,可见红斑-水疱型、坏死-出血型和大泡型。21名患者正在接受抗逆转录病毒治疗(ART),其中6名患者在开始抗逆转录病毒治疗后不久出现HZ。治疗包括口服或静脉注射阿昔洛韦,对于复杂或多特征型和高危患者需要住院治疗。对病情稳定的病例给予密切监测的门诊管理。结论:HZ仍然是PLHIV中重要的机会性感染,通常是未确诊HIV的前哨信号。对HZ患者进行早期HIV筛查和及时开始抗病毒治疗对于改善预后至关重要。提高认识和综合HIV-HZ管理策略在临床实践中至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.60
自引率
7.10%
发文量
144
审稿时长
3-6 weeks
期刊介绍: The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信