Association Between Depression and Lung Cancer Risk Among Postmenopausal Women

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-03-02 DOI:10.1002/cam4.70695

Yuanyuan La, Su Yon Jung, Xiaoyun Liang, Michelle J. Naughton, Michael Hendryx, Juhua Luo

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Abstract

Background

In recent years, the association between depression and various chronic diseases has attracted widespread attention. However, the effect of depression on lung cancer incidence has not been well studied. This study aimed to explore whether depression increases the incidence of lung cancer and to analyze the mediating and moderating roles of smoking in this relationship.

Methods

This study used large-scale longitudinal data sourced from the Women's Health Initiative, encompassing 123,961 postmenopausal women. Depressive symptoms were measured using the 8-item Burnam regression algorithm with a cut-point of 0.06, and depression was defined as either depressive symptoms or antidepressant use at baseline. The relationship between depression and lung cancer incidence was examined using a multivariate Cox proportional hazards regression model. A four-way decomposition causal mediation approach was employed to investigate the potential mediating and moderating effects of smoking.

Results

After a mean follow-up of 17.6 years, 3434 cases of lung cancer were identified. The incidence rate of lung cancer was higher among individuals with depression compared to those without (HR: 1.15, 95% CI: 1.05–1.26). Cigarette smoking partially mediated the relationship between depression and lung cancer incidence, explaining about 27% of the association effect.

Conclusions

This study identified a significant association between depression and lung cancer incidence, and smoking partially mediates this relationship. This highlights that managing depression may play a key role in reducing lung cancer risk and decreasing tobacco use. Psychological support should be integrated with traditional smoking cessation programs for lung cancer prevention.

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.