Engineered Calcium Silicate-Hexaboride Biocomposites: A Versatile Platform for Personalized Orthopedic Therapies

IF 2.8 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Silicon Pub Date : 2025-02-13 DOI:10.1007/s12633-025-03229-3

Gehan T. El-Bassyouni, Shaimaa ElShebiney, Reda Korany, Mostafa Mabrouk, Ahmed Soliman, Hussein Darwish, Sayed Kenawy, Esmat Hamzawy

{"title":"Engineered Calcium Silicate-Hexaboride Biocomposites: A Versatile Platform for Personalized Orthopedic Therapies","authors":"Gehan T. El-Bassyouni, Shaimaa ElShebiney, Reda Korany, Mostafa Mabrouk, Ahmed Soliman, Hussein Darwish, Sayed Kenawy, Esmat Hamzawy","doi":"10.1007/s12633-025-03229-3","DOIUrl":null,"url":null,"abstract":"<div><p>Developing and evaluating enhanced biocomposites for medication delivery and bone regeneration is the main goal of this research. A unique wet precipitation chemical process was used to create calcium silicate (CaO–SiO₂) biocomposites, with different amounts of calcium hexaboride (CaB₆) incorporated as an additive. The biocomposite samples were subjected to varying compositions, and their physicochemical properties were assessed by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and zeta potential tests. The samples' microstructures show submicron and nanoscale particles scattered or arranged in regular or irregular clusters. After adding CaB<sub>6</sub>, the tested biocomposites' negative zeta potential dropped because of the positively charged Ca<sup>2+</sup> ions from the compound on the material's surface. The biocomposites' drug loading and release capacities were assessed using the anti-cancer medication of 5-fluorouracil (5-FU). The biocomposites were evaluated for their capacity to regenerate bone through in vivo experiments conducted on a rat model. The healing score (7 for the WB7.5 sample) and the degree of bone formation were compared with the concentration of CaB₆ in the bio-composites. The findings revealed that the presence of CaB₆ had a substantial impact on both the healing score and bone formation. Increased amounts of CaB₆ resulted in higher healing scores and better bone production. Moreover, the bio-composites demonstrated prolonged drug release profiles (up to 45% after 30 days of immersion), indicating their potential as efficient drug carriers for localized bone treatments. The results emphasize the vital importance of CaB₆ in facilitating the process of bone repair and production using calcium silicate bio-composites. The biocomposites that have been produced show promise for bone regeneration applications. Patient outcomes may benefit from their ability to encourage bone growth and aid in healing.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":776,"journal":{"name":"Silicon","volume":"17 4","pages":"873 - 887"},"PeriodicalIF":2.8000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Silicon","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s12633-025-03229-3","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Developing and evaluating enhanced biocomposites for medication delivery and bone regeneration is the main goal of this research. A unique wet precipitation chemical process was used to create calcium silicate (CaO–SiO₂) biocomposites, with different amounts of calcium hexaboride (CaB₆) incorporated as an additive. The biocomposite samples were subjected to varying compositions, and their physicochemical properties were assessed by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and zeta potential tests. The samples' microstructures show submicron and nanoscale particles scattered or arranged in regular or irregular clusters. After adding CaB₆, the tested biocomposites' negative zeta potential dropped because of the positively charged Ca²⁺ ions from the compound on the material's surface. The biocomposites' drug loading and release capacities were assessed using the anti-cancer medication of 5-fluorouracil (5-FU). The biocomposites were evaluated for their capacity to regenerate bone through in vivo experiments conducted on a rat model. The healing score (7 for the WB7.5 sample) and the degree of bone formation were compared with the concentration of CaB₆ in the bio-composites. The findings revealed that the presence of CaB₆ had a substantial impact on both the healing score and bone formation. Increased amounts of CaB₆ resulted in higher healing scores and better bone production. Moreover, the bio-composites demonstrated prolonged drug release profiles (up to 45% after 30 days of immersion), indicating their potential as efficient drug carriers for localized bone treatments. The results emphasize the vital importance of CaB₆ in facilitating the process of bone repair and production using calcium silicate bio-composites. The biocomposites that have been produced show promise for bone regeneration applications. Patient outcomes may benefit from their ability to encourage bone growth and aid in healing.

Graphical Abstract

查看原文本刊更多论文

硅酸钙-六硼酸工程生物复合材料：个性化矫形治疗的多功能平台

开发和评估用于给药和骨再生的增强型生物复合材料是本研究的主要目标。研究人员采用独特的湿沉淀化学工艺制造硅酸钙（CaO-SiO₂）生物复合材料，并加入不同量的六硼化钙（CaB₆）作为添加剂。对生物复合材料样品进行了不同成分的测试，并通过 X 射线衍射（XRD）、场发射扫描电子显微镜（FE-SEM）和 zeta 电位测试评估了它们的理化性质。样品的微观结构显示出亚微米和纳米级颗粒分散或排列成规则或不规则的团块。添加 CaB6 后，由于材料表面的化合物带正电 Ca2+ 离子，测试生物复合材料的负 zeta 电位下降。使用抗癌药物 5-氟尿嘧啶（5-FU）对生物复合材料的药物负载和释放能力进行了评估。通过在大鼠模型上进行体内实验，评估了生物复合材料的骨再生能力。将愈合评分（WB7.5 样品为 7 分）和骨形成程度与生物复合材料中 CaB₆ 的浓度进行了比较。研究结果表明，CaB₆ 的存在对愈合评分和骨形成都有很大影响。CaB₆ 含量的增加会导致愈合评分更高，骨形成更好。此外，生物复合材料还表现出较长的药物释放曲线（浸泡 30 天后释放高达 45%），这表明它们有潜力成为局部骨治疗的高效药物载体。研究结果强调了 CaB₆ 在利用硅酸钙生物复合材料促进骨骼修复和生成过程中的重要作用。已生产出的生物复合材料显示了骨再生应用的前景。它们能够促进骨骼生长和帮助愈合，从而使患者受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Silicon CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.90

自引率

20.60%

发文量

685

审稿时长

>12 weeks

期刊介绍： The journal Silicon is intended to serve all those involved in studying the role of silicon as an enabling element in materials science. There are no restrictions on disciplinary boundaries provided the focus is on silicon-based materials or adds significantly to the understanding of such materials. Accordingly, such contributions are welcome in the areas of inorganic and organic chemistry, physics, biology, engineering, nanoscience, environmental science, electronics and optoelectronics, and modeling and theory. Relevant silicon-based materials include, but are not limited to, semiconductors, polymers, composites, ceramics, glasses, coatings, resins, composites, small molecules, and thin films.