Prostate as a target of endocrine disrupting chemicals: Relevance, pathways, assays

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-02-27 DOI:10.1016/j.reprotox.2025.108867

Daniele Marcoccia , Marta Mollari , Flavia Silvia Galli , Camilla Cuva , Valentina Tassinari , Alberto Mantovani

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Abstract

Prostate, the main accessory gland of the male reproductive system, is a critical but yet overlooked target for Endocrine Disruptors (EDs), affecting the male reproductive system. Prostate is essential for male fertility; indeed, the prostatic fluid is the main component of seminal fluid, which is essential for the activation and capacitation of sperm cells. Furthermore, the prostate is tightly regulated by androgen signaling and is an important site for endocrine-related tumorigenesis. The following systematic review assesses and discusses the available literature evidence regarding the use of the androgen-dependent human prostate cell line LNCaP, in which up- or down-regulation of androgen signaling is assessed by measuring a clinically relevant marker, the Prostate-Specific Antigen (PSA). The data set is still limited: 30 articles, mainly dealing on natural substances and plant extracts, met the eligibility criteria. However, the results support the potential of the PSA assay testing on LNCaP cells in evaluating endocrine-related effects on prostate function as well as to identifying substances that may affect androgen-regulated pathways. Overall, the findings encourage further investigations with a broader range of substances with different modes of action.

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前列腺作为内分泌干扰物的靶标：相关性，途径，分析

前列腺是男性生殖系统的主要附属腺体，是影响男性生殖系统的内分泌干扰物（EDs）的一个重要但却被忽视的靶点。前列腺对男性生育能力至关重要；事实上，前列腺液是精液的主要成分，对精子细胞的激活和获能至关重要。此外，前列腺受雄激素信号的严格调控，是内分泌相关肿瘤发生的重要部位。下面的系统综述评估和讨论了使用雄激素依赖性人前列腺细胞系LNCaP的现有文献证据，其中雄激素信号的上调或下调是通过测量临床相关标志物前列腺特异性抗原（PSA）来评估的。数据集仍然有限：30篇文章符合资格标准，主要涉及天然物质和植物提取物。然而，这些结果支持了PSA检测LNCaP细胞在评估内分泌对前列腺功能的影响以及识别可能影响雄激素调节途径的物质方面的潜力。总的来说，这些发现鼓励了对具有不同作用模式的更广泛物质的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.