Prostate as a target of endocrine disrupting chemicals: Relevance, pathways, assays

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-02-27 DOI:10.1016/j.reprotox.2025.108867

Daniele Marcoccia , Marta Mollari , Flavia Silvia Galli , Camilla Cuva , Valentina Tassinari , Alberto Mantovani

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引用次数: 0

Abstract

Prostate, the main accessory gland of the male reproductive system, is a critical but yet overlooked target for Endocrine Disruptors (EDs), affecting the male reproductive system. Prostate is essential for male fertility; indeed, the prostatic fluid is the main component of seminal fluid, which is essential for the activation and capacitation of sperm cells. Furthermore, the prostate is tightly regulated by androgen signaling and is an important site for endocrine-related tumorigenesis. The following systematic review assesses and discusses the available literature evidence regarding the use of the androgen-dependent human prostate cell line LNCaP, in which up- or down-regulation of androgen signaling is assessed by measuring a clinically relevant marker, the Prostate-Specific Antigen (PSA). The data set is still limited: 30 articles, mainly dealing on natural substances and plant extracts, met the eligibility criteria. However, the results support the potential of the PSA assay testing on LNCaP cells in evaluating endocrine-related effects on prostate function as well as to identifying substances that may affect androgen-regulated pathways. Overall, the findings encourage further investigations with a broader range of substances with different modes of action.

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.