Endoscopic findings among healthy adults with asymptomatic norovirus infection in Japan: A single-center cross-sectional study

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-02-27 DOI:10.1016/j.jiac.2025.102672

Kyoko Yokota , Hisashi Masugata , Shizuka Yamagata-Uyama , Kazuki Yamamoto , Katsunori Masuda , Mayuko Saito , Daiki Kobayashi

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引用次数: 0

Abstract

Introduction

Norovirus infection, a major cause of acute viral gastroenteritis, is commonly reported during the winter season. Norovirus invades the upper intestinal tract, causing inflammation. In severe cases, endoscopic findings and complications, including duodenal perforation, have been reported. However endoscopic findings in patients with asymptomatic infections have rarely been reported. Therefore, this study aimed to investigate the upper endoscopic findings of patients with asymptomatic norovirus infection.

Methods

Healthy adults (aged ≥18 years) who participated in voluntary health examinations between February 2017 and January 2018 were recruited twice a week. Only the individuals who had undergone esophagogastroduodenoscopy (EGD) were included. The primary outcome measure was the presence of any gross findings of EGD.

Results

The norovirus genogroup I (GI)-positive group had more duodenal scarring than the norovirus negative group (16.3 % vs 5.9 %, respectively). After adjustment for age category, sex, and alcohol consumption status, duodenal ulcer scarring exhibited a significant association with GI-positive status (adjusted odds ratio: 3.11; 95 % confidence interval: 1.42–6.82; p = 0.005, Bonferroni-corrected, p = 0.015).

Conclusions

Healthy adults with asymptomatic norovirus (GI-positive) infection showed predominantly more duodenal ulcer scarring than the norovirus-negative group on EGD.

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.