Collagen-based hydrogel sol-gel phase transition mechanism and their applications

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2025-02-22 DOI:10.1016/j.cis.2025.103456

Xia Yang , Khurshid Ahmad , Tingting Yang , Yan Fan , Fei Zhao , Shanshan Jiang , Peng Chen , Hu Hou

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引用次数: 0

Abstract

Collagen-based hydrogels represent a crucial class of biomaterials for their desirable physicochemical and biochemical properties. The variation in ingredients, gelation conditions, and crosslinking techniques may impact the physicochemical and biological properties of collagen-based hydrogels. However, the specific effects of these parameters on the gelation mechanisms of novel hydrogels and the relationships between fabrication parameters and the resultant characteristics of these hydrogels remain elusive. This review discussed the sol-gel phase transition mechanisms of collagen-based hydrogels, emphasizing the impact of gelation conditions, crosslinking agents, and additional polymers. This article highlights the potential of natural ingredients and safe modification technologies as effective strategies to mitigate the harmful effects of synthetic toxic components in products. Furthermore, this review summarizes constitutive models of collagen hydrogels, which serve as valuable tools for designing and customizing hydrogels to meet specific application requirements by simulating their mechanical and rheological properties. Additionally, the article concludes by briefly introducing applications of novel collagen-based hydrogels with desirable functions and properties. This review further deals with the theoretical support for the rational design and customization of innovative hydrogels and inspires future collagen-based biomaterial development.

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.