Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102188

Takumi Muramatsu , Masato Kono , Masaki Ishige , Takahiko Saito , Misato Higasa , Fumiya Nihashi , Yuya Aono , Mineo Katsumata , Hideki Miwa , Yoshihiro Miki , Taro Misaki , Yoshiro Otsuki , Dai Hashimoto , Noriyuki Enomoto , Takafumi Suda , Hidenori Nakamura

{"title":"Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review","authors":"Takumi Muramatsu , Masato Kono , Masaki Ishige , Takahiko Saito , Misato Higasa , Fumiya Nihashi , Yuya Aono , Mineo Katsumata , Hideki Miwa , Yoshihiro Miki , Taro Misaki , Yoshiro Otsuki , Dai Hashimoto , Noriyuki Enomoto , Takafumi Suda , Hidenori Nakamura","doi":"10.1016/j.rmcr.2025.102188","DOIUrl":null,"url":null,"abstract":"<div><div>A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously. Computed tomography revealed centrilobular micronodules and bronchovascular bundle thickening in both lungs with multicentric lymphadenopathies; multiple pulmonary nodular lesions appeared during prednisolone tapering. Laboratory findings included polyclonal hypergammaglobulinemia and elevated interleukin-6 levels. Surgical lung biopsy revealed marked lymphoplasmacytic infiltration with lymphoid aggregates. The patient tested negative for human herpesvirus-8 and clinically diagnosed with idiopathic multicentric Castleman disease. The coexistence of sarcoidosis and Castleman disease is rare; this case improved with additional tocilizumab treatment.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"54 ","pages":"Article 102188"},"PeriodicalIF":0.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Medicine Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213007125000243","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously. Computed tomography revealed centrilobular micronodules and bronchovascular bundle thickening in both lungs with multicentric lymphadenopathies; multiple pulmonary nodular lesions appeared during prednisolone tapering. Laboratory findings included polyclonal hypergammaglobulinemia and elevated interleukin-6 levels. Surgical lung biopsy revealed marked lymphoplasmacytic infiltration with lymphoid aggregates. The patient tested negative for human herpesvirus-8 and clinically diagnosed with idiopathic multicentric Castleman disease. The coexistence of sarcoidosis and Castleman disease is rare; this case improved with additional tocilizumab treatment.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊