An Injectable Copolymer for in Situ Lubrication Effectively Relieves Dry Eye Disease

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2025-02-07 DOI:10.1021/acsmaterialslett.4c0232710.1021/acsmaterialslett.4c02327

Lan Yang, Jinghua Li, Bowen Zhou and Yi Wang*,

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Abstract

The current lubricating artificial tear ingredient for dry eye disease (DED) therapy, i.e., sodium hyaluronate (SH), is ineffective because it is difficult to stay on the ocular surface long term. To address this problem, we developed an injectable in situ lubricative copolymer that can firmly adhere to the ocular surface for long-lasting in situ lubrication. Lubrication was achieved by the zwitterionic monomer [2-((methacryloyl)oxy)ethyl]phosphorylcholine (MPC) with hydration lubrication property. Meanwhile, in situ adhesion performance was achieved by the reactive ester monomer N-hydroxysuccinimidyl acrylate (AA-NHS), which is capable of amide bonding reactions to the tissue surface. The optimum feeding ratio of MPC versus AA-NHS for free radical polymerization was confirmed by friction tests, and this group was named MPC-co-AA-NHS (MAN). We established a BALB/c mice DED model to verify its biofunctionality in vivo. The results showed that MAN is a promising in situ lubrication material that effectively relieves DED.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.