Association of PM2.5-bound multiple metals co-exposure with early cardiovascular damage: A panel study in young adults combing metabolomics

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-03-02 DOI:10.1016/j.envpol.2025.125964

Junjie Chen, Qingfeng Zhou, Yingrong Wang, Yuting Wu, Miao Li, Haotian Wang, Guoying Zheng, Yulan Hao, Xiangke Cao, Wenqi Yang, Lei Zhang, Qian Wang

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Abstract

The association of individual metals in PM_2.5 with cardiovascular damage has been established in previous studies, but there are fewer studies on co-exposure to multiple metals and potential metabolic alterations in cardiovascular damage. To investigate the early cardiovascular effects of multiple metals and the mediating effects of metabolites, we conducted a panel study on young adults from 2017 Winter to 2018 Autumn in Caofeidian, China. A total of 180 serum samples were analyzed for metabolomic profiles using liquid chromatography-mass spectrometry. The associations between personal metal exposure, metabolite levels, and indicators of cardiovascular injury were analyzed by linear mixed-effects modeling (LEM) and Bayesian kernel machine regression (BKMR). Metabolomic analyses showed 79 metabolites in the serum of healthy adults changed significantly between seasons and all metabolites were strongly associated with toxic metals. Additionally, differential metabolites were enriched in seven metabolic pathways and activated by metal exposure, such as Butanoate metabolism and Linoleic acid metabolism. BKMR model interpreted that the overall effect of metals mixture was negatively associated with Capryloyl glycine and Sphinganine and Sb mainly contributed to the effect. The results of mediation analysis revealed that the association between V and VEGF was mediated by Diethylhexyl with a partial proportion of 13.4%. Furthermore, the result also found the association between CerP(d18:1/26:1(17Z)) and ET-1 was mediated by TGFβ1 with a proportion of 53.4%. Our findings suggested that multiple metal exposure was associated with metabolomic changes of cardiovascular damage in young adults, and may simultaneously affect the metabolomic changes by inducing oxidative stress and inflammation.

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PM2.5中的单个金属与心血管损伤的相关性已在以往的研究中得到证实，但关于多种金属的共同暴露和心血管损伤的潜在代谢改变的研究较少。为了探究多种金属对心血管的早期影响以及代谢物的中介效应，我们于2017年冬季至2018年秋季在中国曹妃甸开展了一项针对青壮年的面板研究。采用液相色谱-质谱联用技术对共计180份血清样本进行了代谢组学分析。通过线性混合效应模型（LEM）和贝叶斯核机回归（BKMR）分析了个人金属暴露、代谢物水平和心血管损伤指标之间的关联。代谢组学分析表明，健康成年人血清中的 79 种代谢物在不同季节有显著变化，所有代谢物都与有毒金属密切相关。此外，不同的代谢物富集在七个代谢途径中，并被金属暴露激活，如丁酸代谢和亚油酸代谢。BKMR 模型解释了金属混合物的总体效应与辛酰甘氨酸和鞘氨醇呈负相关，而锑则是造成这种效应的主要原因。中介分析结果显示，V 与血管内皮生长因子之间的关联是由二乙基己基中介的，部分比例为 13.4%。此外，结果还发现 CerP（d18:1/26:1(17Z)）与 ET-1 之间的关联是由 TGFβ1 介导的，所占比例为 53.4%。我们的研究结果表明，多种金属暴露与青壮年心血管损伤的代谢组变化有关，并可能同时通过诱导氧化应激和炎症影响代谢组变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.