The use of tranexamic acid for post-tonsillectomy hemorrhage: A scoping review protocol.

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

PLoS ONE Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0319284

Naomi Tesema, Sukaina Hasnie, Marisa Earley, Max April

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引用次数: 0

Abstract

Background: Post-tonsillectomy hemorrhage (PTH) is a highly studied outcome of tonsillectomy with serious consequences. Various treatments and interventions have been utilized to decrease post-tonsillectomy hemorrhage. The off-label use of tranexamic acid (TXA) is of growing interest to control PTH but has not been incorporated in management guidelines. This scoping review plans to summarize existing studies from the scientific literature on the use of tranexamic acid for post-tonsillectomy hemorrhage.

Methods: We used the Preferred Reporting Items for Systematic Reviews or Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR). The review will cover studies including patients undergoing tonsillectomy who were treated with TXA in the peri-operative or post-operative period. We include randomized controlled trials, retrospective, prospective, and case series. A database-specific search strategy will be used to search records across. Two reviewers will independently screen and extract data. Tables and visual representations will be utilized to present the extracted data.

Registration details: The protocol will be registered in Open Science Framework and published in PLOS One.

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背景：扁桃体切除术后出血（PTH）是扁桃体切除术的一个重要研究结果，其后果十分严重。为减少扁桃体切除术后出血，人们采取了各种治疗和干预措施。标示外使用氨甲环酸（TXA）来控制 PTH 越来越受到关注，但尚未纳入管理指南。本范围界定综述计划总结现有科学文献中关于使用氨甲环酸治疗扁桃体切除术后出血的研究：方法：我们采用了 "范围界定综述的系统综述或荟萃分析扩展首选报告项目"（PRISMA-ScR）。该综述将涵盖扁桃体切除术患者在围手术期或术后使用 TXA 治疗的研究。我们将纳入随机对照试验、回顾性研究、前瞻性研究和病例系列研究。我们将使用数据库特定的搜索策略来搜索所有记录。两名审稿人将独立筛选和提取数据。将使用表格和可视化方式展示提取的数据：该协议将在开放科学框架中注册，并在 PLOS One 上发表。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS ONE 生物-生物学

CiteScore

6.20

自引率

5.40%

发文量

14242

审稿时长

3.7 months

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