Characterization and in vitro cellular activity assessment of photodynamic composite nanocarriers for gliomas treatment

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-03-01 DOI:10.1007/s11051-025-06268-4

Yongxu Yang, Wenxiu Li, Junhong Zhou, Yang Yu, Shujie Liu, Qing Xu

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Abstract

Glioblastoma (GBM) originates from cancerous cells of the central nervous system (CNS) in the brain and spinal cord, and is the most common malignant primary tumor in brain tumors, with a high degree of aggressiveness and resistance to treatment, accounting for 48.6% of CNS malignant tumors. Although metal–organic frameworks (MOFs) have been widely used in drug delivery, developing nanocarriers with both high stability and biocompatibility remains a significant challenge. This study developed a novel composite nano drug delivery system, PLGA-PDI@CP1@1, which combines poly(lactic-co-glycolic acid) (PLGA) and perylene diimide (PDI) with excellent fluorescence properties to effectively encapsulate MOF-based CP1. The system was further loaded with an active compound extracted from ginseng (compound 1) for the treatment of gliomas. Through in vitro cellular experiments, we found that PLGA-PDI@CP1@1 was able to inhibit the proliferation of cancer cells by suppressing the expression of the glioma proliferation-associated gene MAGED4.

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.