{"title":"NiCu-layered double hydroxide–modified CuO nanorods for enhanced non-enzymatic glucose sensing","authors":"Jiahao Yang, Lan Xu","doi":"10.1007/s00604-025-07061-9","DOIUrl":null,"url":null,"abstract":"<div><p>A flexible non-enzymatic glucose sensor with high sensitivity (NiCu-LDH/CuO/NCC) was prepared by growing NiCu-layered double hydroxide (NiCu-LDH)–modified CuO nanorods on N-doped carbon cloth (NCC) using hydrothermal method and electrodeposition. The NCC provided abundant attachment sites and good electrical conductivity for CuO nanorods, and the hierarchical nanostructures (NiCu-LDH/CuO) had large specific surface area and highly catalytic active sites, which facilitated the electrooxidation of glucose. The effect of the ratio of Ni to Cu on the electrocatalytic performance of NiCu-LDH/CuO/NCC was evaluated. The results indicated that the optimized NiCu-LDH/CuO/NCC (Ni/Cu molar ratio of 2:1) had good electrocatalytic oxidation toward glucose, and exhibited high sensitivity (11.545 mA cm<sup>−2</sup> mM<sup>−1</sup>), low detection limit (0.26 μM), large linear range (0.001–1.5 mM), and good stability (95% after 28 days). Therefore, the hierarchical nanostructure is suitable for the construction of flexible non-enzymatic glucose sensors with high sensitivity, indicating that the combination of transition metal oxides and LDH provides a unique opportunity for designing high-performance electrochemical non-enzymatic glucose sensors.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07061-9","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
A flexible non-enzymatic glucose sensor with high sensitivity (NiCu-LDH/CuO/NCC) was prepared by growing NiCu-layered double hydroxide (NiCu-LDH)–modified CuO nanorods on N-doped carbon cloth (NCC) using hydrothermal method and electrodeposition. The NCC provided abundant attachment sites and good electrical conductivity for CuO nanorods, and the hierarchical nanostructures (NiCu-LDH/CuO) had large specific surface area and highly catalytic active sites, which facilitated the electrooxidation of glucose. The effect of the ratio of Ni to Cu on the electrocatalytic performance of NiCu-LDH/CuO/NCC was evaluated. The results indicated that the optimized NiCu-LDH/CuO/NCC (Ni/Cu molar ratio of 2:1) had good electrocatalytic oxidation toward glucose, and exhibited high sensitivity (11.545 mA cm−2 mM−1), low detection limit (0.26 μM), large linear range (0.001–1.5 mM), and good stability (95% after 28 days). Therefore, the hierarchical nanostructure is suitable for the construction of flexible non-enzymatic glucose sensors with high sensitivity, indicating that the combination of transition metal oxides and LDH provides a unique opportunity for designing high-performance electrochemical non-enzymatic glucose sensors.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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