Effect of a school-based tutorial about the HPV vaccine for female middle school students on the HPV vaccination rate in Japan: A prospective cohort study

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-02-26 DOI:10.1016/j.jiac.2025.102671

Yo Murata , Yuya Saito , Toshimasa Obonai

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引用次数: 0

Abstract

Background

In Japan, the Ministry of Health, Labour and Welfare (MHLW) rescinded recommendations for including the HPV vaccine in the national immunization program in 2013, which led to a drop in the vaccination rate to < 1 %. Despite the MHLW's decision to reinstate the recommendations in 2022, the vaccination rate has remained low. The present study aimed to assess the effect of a school-based vaccine tutorial on the HPV vaccination rate in female middle-school students in Japan.

Methods

This prospective cohort study, conducted in Higashimurayama, Tokyo from September 2023 to March 2024, enrolled female students aged 13–14 years in seven middle schools. Four and three schools formed a tutorial group and control group, respectively. The difference between the pre- and post-intervention vaccination rates was assessed using a questionnaire. Additionally, knowledge about the HPV vaccine and the rate of students’ discussion of the vaccine with their family were analyzed.

Results

In total, 123 and 175 students from the tutorial and control group, respectively, were analyzed. The pre-intervention vaccination rate was 9.8 % and 7.4 % (p = 0.476), and the post-intervention vaccination rate was 16.3 % and 9.7 %, indicating a corresponding increase of 7.2 % and 2.5 % (p = 0.075). The knowledge increased to a greater degree in the tutorial group.

Conclusion

Our study revealed an increasing trend in the HPV vaccination rate resulting from the school-based tutorial although the difference was not statistically significant. School-based tutorials can increase students’ knowledge about the vaccine and enable them to make informed decisions about vaccination.

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日本女中学生HPV疫苗校本教程对HPV疫苗接种率的影响：一项前瞻性队列研究

在日本，厚生劳动省（MHLW）于2013年取消了将HPV疫苗纳入国家免疫规划的建议，这导致疫苗接种率降至1%。1%。尽管卫生和社会福利部决定在2022年恢复这些建议，但疫苗接种率仍然很低。本研究旨在评估以学校为基础的疫苗教程对日本女中学生HPV疫苗接种率的影响。方法本前瞻性队列研究于2023年9月至2024年3月在东京东村山进行，招募了7所中学13-14岁的女学生。四所学校和三所学校分别组成了导师组和对照组。干预前和干预后疫苗接种率的差异用问卷进行评估。此外，还分析了HPV疫苗的知识和学生与家人讨论疫苗的比率。结果导师组和对照组分别分析了123名和175名学生。干预前接种率分别为9.8%和7.4% (p = 0.476)，干预后接种率分别为16.3%和9.7%，分别提高了7.2%和2.5% （p = 0.075）。导师组的知识增长幅度更大。结论本研究显示，学校导师制对HPV疫苗接种率有提高的趋势，但差异无统计学意义。以学校为基础的教程可以增加学生对疫苗的了解，使他们能够在知情的情况下做出疫苗接种的决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.