Ultrasound-assisted natural deep eutectic solvents extraction of flavonoids from Hippophae rhamnoides: Optimization and kinetics studies

IF 3.8 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-02-23 DOI:10.1016/j.cep.2025.110244

Chenlu Han , Ziwei Yang , Xiaoqiang Chen , Lin Yan , Ying Zhang

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Abstract

Flavonoids are important bioactive components in Hippophae rhamnoides. In this study, flavonoids were extracted from H. rhamnoides leaves with an ultrasonic-assisted natural deep eutectic solvent. The optimal conditions included a molar ratio of 1:3, a liquid–solid ratio of 40 mL/g, and an extraction time of 30 min, and the extraction yield was 18.70 % ± 0.25 %. A model of the kinetics was developed to describe the extraction of flavonoids using Fick's law as the basis, where the rate constant and diffusion coefficient increased with the temperature, highlighting the pronounced influence of the temperature on the extraction efficiency. Following simulated digestion, the bioaccessibility index showed that 78.21 % of the flavonoids could be absorbed by tissues. These results will be beneficial for achieving the efficient extraction of flavonoids and the full exploitation and utilization of sea buckthorn resources.

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黄酮类化合物是鼠李中重要的生物活性成分。本研究采用超声波辅助天然深共晶溶剂萃取鼠李叶中的黄酮类化合物。最佳条件包括摩尔比为 1:3，液固比为 40 mL/g，萃取时间为 30 分钟，萃取率为 18.70 % ± 0.25 %。以菲克定律为基础，建立了黄酮类化合物萃取动力学模型，其中速率常数和扩散系数随温度升高而增大，凸显了温度对萃取效率的显著影响。模拟消化后，生物可及性指数显示，78.21%的黄酮类化合物可被组织吸收。这些结果将有助于实现黄酮类化合物的高效提取，充分开发和利用沙棘资源。

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来源期刊

Chemical Engineering and Processing - Process Intensification 工程技术-工程：化工

CiteScore

7.80

自引率

9.30%

发文量

408

审稿时长

49 days

期刊介绍： Chemical Engineering and Processing: Process Intensification is intended for practicing researchers in industry and academia, working in the field of Process Engineering and related to the subject of Process Intensification.Articles published in the Journal demonstrate how novel discoveries, developments and theories in the field of Process Engineering and in particular Process Intensification may be used for analysis and design of innovative equipment and processing methods with substantially improved sustainability, efficiency and environmental performance.