Evaluation of salusin-β in paediatric patients with chronic kidney disease or hypertension

IF 2.5 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Mirjam Močnik , Sonja Golob Jančič , Martina Filipič , Evgenija Homšak , Mateja Svetej , Nataša Marčun Varda
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引用次数: 0

Abstract

Purpose

Salusins are newly identified endogenous peptides implicated in the atherosclerotic process. Salusin-β, in particular, is recognized for its proatherogenic role. Given that atherosclerosis can commence in childhood, salusin-β holds promise as a potential biomarker for cardiovascular risk assessment. The objective of our study was to investigate salusin-β levels in children with early stages of chronic kidney disease (CKD) or hypertension (HTN), and compare them to healthy controls. Furthermore, we aimed to evaluate its association with obesity and pulse wave velocity (PWV), the latter being a well-established marker for determining arterial elasticity.

Materials and methods

This cross-sectional study involved 96 paediatric patients, including 46 with CKD and 50 with HTN, as well as 33 healthy controls. Anthropometric measurements, PWV assessments, serum salusin-β values, and basic laboratory investigations were conducted for all participants.

Results

Salusin-β levels were found to be elevated in patients with CKD (p ​= ​0.014), but not in patients with HTN when compared to healthy controls. When correlating salusin-β levels with PWV, a significant but weak correlation was observed (r ​= ​0.211, p ​= ​0.020).

Conclusions

Salusin-β levels were elevated in paediatric patients with CKD. Additionally, salusin-β levels correlated significantly with PWV. Obesity played a smaller role in these correlations, with significant correlations observed only after combining cardiovascular risk factors revealing certain associations between salusin-β levels and some cardiovascular variables, but with inconclusive findings and, in some instances, even contrary to anticipated outcomes.

Abstract Image

慢性肾病或高血压患儿salusin-β的评价
目的alusins是新发现的与动脉粥样硬化过程有关的内源性肽。特别是Salusin-β,被认为具有促进动脉粥样硬化的作用。鉴于动脉粥样硬化可以在儿童时期开始,salusin-β有望成为心血管风险评估的潜在生物标志物。本研究的目的是调查早期慢性肾脏疾病(CKD)或高血压(HTN)儿童的salusin-β水平,并将其与健康对照进行比较。此外,我们旨在评估其与肥胖和脉搏波速度(PWV)的关系,后者是确定动脉弹性的公认标志。材料和方法本横断面研究纳入96例儿科患者,包括46例CKD患者和50例HTN患者,以及33例健康对照。对所有参与者进行了人体测量、PWV评估、血清salusin-β值和基础实验室调查。结果与健康对照相比,CKD患者的salusin -β水平升高(p = 0.014),而HTN患者的salusin -β水平没有升高。当salusin-β水平与PWV相关时,观察到显著但微弱的相关性(r = 0.211, p = 0.020)。结论儿童CKD患者salusin -β水平升高。此外,salusin-β水平与PWV显著相关。肥胖在这些相关性中所起的作用较小,只有在结合心血管危险因素揭示salusin-β水平与一些心血管变量之间的某些关联后,才能观察到显著的相关性,但结果不确定,在某些情况下,甚至与预期结果相反。
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来源期刊
Advances in medical sciences
Advances in medical sciences 医学-医学:研究与实验
CiteScore
5.00
自引率
0.00%
发文量
53
审稿时长
25 days
期刊介绍: Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.
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