Carboxymethyl chitosan hydrogel network constructed PES ultrafiltration membrane to separate bovine serum albumin from collagen

IF 8.1 1区工程技术 Q1 ENGINEERING, CHEMICAL

Separation and Purification Technology Pub Date : 2025-02-28 DOI:10.1016/j.seppur.2025.132314

Yafang Wu, Yujia Tong, Li Zhang, Xiaohui Ju, Chenxuan Shao, Qi Zhang, Weixing Li, Weihong Xing

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引用次数: 0

Abstract

Ultrafiltration membrane for purification of proteins represents a significant research challenge. In order to improve the uniformity of membrane pores, carboxymethyl chitosan hydrogel (TB-g-MC) grafted by methacrylic anhydride and 2, 3, 4-trihydroxybenzaldehyd was proposed to construct polyethersulfone (PES) ultrafiltration membrane with crosslinked network. TB-g-MC with better hydrophilicity could effectively slow down the phase transition process, which led to more uniform membrane pores. The water flux of the PES/TB-g-MC membrane arrived at 880.2 L·m⁻²·h⁻¹, three times higher than that of the pristine membrane. The rejection of bovine serum albumin (BSA) was 99.5 % with the collagen permeability of 99.9 %, which showed that the developed membrane had narrow pore size distribution and better separation performance. Furthermore, it exhibited noteworthy anti-fouling characteristics with the flux recovery of 90 %. The proposed membrane with hydrogel network structure will be prospective for protein purification and production in biomedical field.

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来源期刊

Separation and Purification Technology 工程技术-工程：化工

CiteScore

14.00

自引率

12.80%

发文量

2347

审稿时长

43 days

期刊介绍： Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.