Efficacy of Pulp Revascularization in the Treatment of Apical Periodontitis in Mature Necrotic Teeth: An Umbrella Review.

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2025-02-28 DOI:10.1111/aej.12928

Wanderson Limeira de Sousa Barbosa, Luiz Renato Paranhos, Márcia Valente de Brito Dantas, Rômulo Dias Jesuino, João Marcos da Costa Ribeiro, Walbert A Vieira, Felipe de Souza Matos

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引用次数: 0

Abstract

This umbrella review evaluated systematic reviews in clinical studies on pulp revascularisation in permanent mature necrotic teeth to determine their effectiveness in treating or preventing apical periodontitis. Seven of 294 articles retrieved from PubMed, LILACS, SciELO, Embase, Scopus, Web of Science, Cochrane and DANS Easy databases were included. The most used pulp revascularisation techniques were blood clots associated or not with platelet-poor plasma and umbilical cord mesenchymal stem cells. Meta-analysis and qualitative results from included articles indicated the efficacy of pulp revascularisation in mature necrotic teeth with similar success rates compared to non-surgical root canal treatment, pulp revascularisation in immature teeth, or apexification. Despite the low methodological quality and high risk of bias in most analysed systematic reviews, pulp revascularisation may be a successful treatment alternative for mature necrotic teeth. Well-conducted clinical trials are required to provide confirmatory evidence.

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.