Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study.

IF 6.5 1区医学 Q1 NUTRITION & DIETETICS

American Journal of Clinical Nutrition Pub Date : 2025-02-25 DOI:10.1016/j.ajcnut.2025.02.026

Qi Wu, Shanshan Bian, Cheng Cheng, Xukun Chen, Liyang Zhang, Li Huang, Tongtong Li, Ruiting Yan, Huilian Duan, Zehao Wang, Yuan Li, Tongyang Wu, Yue Wang, Yan Chen, Xiping Deng, Yongjie Chen, Meilin Zhang, Fei Ma, Wen Li, Guowei Huang

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引用次数: 0

Abstract

Background: There is no specific dietary pattern for cardiometabolic health based on Chinese food culture.

Objectives: The study aimed to develop and assess the efficacy of the reducing cardiometabolic disease risk (RCMDR) dietary pattern on cardiometabolic disease risk in the Chinese population with dyslipidemia.

Methods: In this single-center, open-label, randomized, 12-wk dietary intervention study, 100 adults aged 35-45 y with dyslipidemia were randomly assigned (1:1) to the RCMDR dietary pattern intervention or general health education control group.

Results: Compared with the control group, the RCMDR dietary pattern intervention resulted in a significantly lower clustered cardiometabolic risk score (primary outcome) (β: -0.17; 95% CI: -0.29, -0.05); diastolic blood pressure (β: -0.23; 95% CI: -0.40, -0.07); total cholesterol, LDL cholesterol, triglyceride (β: -0.27; 95% CI: -0.49, -0.04; β: -0.24; 95% CI: -0.41, -0.07; and β: -0.19; 95% CI: -0.35, -0.04, respectively); homocysteine (β: -0.19; 95% CI: -0.28, -0.09); waist circumference, waist-to-hip ratio, body fat percentage, body fat mass, visceral adipose tissue, visceral fat area, and a significantly higher lean body mass (β: -1.12; 95% CI: -1.65, -0.59; β: -1.01; 95% CI: -1.66, -0.36; β: -1.43; 95% CI: -1.87, -0.98; β: -0.98; 95% CI: -1.35, -0.60; β: -1.93; 95% CI: -2.75, -1.11; β: -6.52; 95% CI: -9.10, -3.95; and β: 1.24; 95% CI: 0.84, 1.65, respectively).

Conclusions: Compared with the control group, the RCMDR dietary pattern intervention lowers cardiometabolic risk, blood lipids, blood pressure, abdominal obesity, and circulating homocysteine concentration among Chinese population with dyslipidemia.

Clinical trial registry: This trial was registered at Chinese Clinical Trial Registry as ChiCTR2300072472 (https://www.chictr.org.cn/showproj.html?proj=198618).

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来源期刊

American Journal of Clinical Nutrition 医学-营养学

CiteScore

12.40

自引率

4.20%

发文量

332

审稿时长

38 days

期刊介绍： American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism. Purpose: The purpose of AJCN is to: Publish original research studies relevant to human and clinical nutrition. Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits. Encourage public health and epidemiologic studies relevant to human nutrition. Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches. Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles. Peer Review Process: All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.