Integrating narrative and bibliometric approaches to examine factors and impacts of tuberculosis treatment non-compliance.

IF 2 Q3 RESPIRATORY SYSTEM
Agus Santosa, Neti Juniarti, Tuti Pahria, Raini Diah Susanti
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引用次数: 0

Abstract

Background: Tuberculosis (TB) treatment non-compliance remains a significant global public health issue, undermining disease control efforts and leading to adverse clinical and epidemiological outcomes. While considerable research has explored this issue, gaps remain in understanding the multifactorial influences on non-compliance, particularly its key factors and impacts, as well as the interconnections that exacerbate these challenges. This study integrates narrative and bibliometric approaches to critically synthesize and visualize factors contributing to TB treatment non-compliance and its impacts. By addressing research gaps, this study aims to provide a comprehensive framework for understanding the multifactorial challenges and proposing evidence-informed strategies to address clinical and epidemiological issues.

Methods: A systematic search of Scopus, EBSCO (Medline), ScienceDirect, and PubMed databases identified empirical studies published up to December 2024. Thematic synthesis categorized factors into overarching themes, while bibliometric analysis using VOSviewer software visualized factors and their interconnections.

Results: The review identified key factors such as poor tuberculosis knowledge, stigma, side effects, and economic constraints, interacting with demographic, psychological, and systemic barriers. Network visualization highlighted the interconnections among these factors, illustrating how they compound to exacerbate non-compliance. Clinical and epidemiological impacts include MDR/XDR-TB, prolonged treatment, and community transmission.

Conclusions: TB treatment non-compliance arises from a complex interplay of individual, socio-economic, and healthcare-related factors. This review emphasizes the importance of integrated narrative and bibliometric approaches to develop context-specific strategies for improving adherence, reducing the global TB burden, and guiding future research and policy.

整合叙述和文献计量方法来检查结核病治疗不依从性的因素和影响。
背景:结核病(TB)治疗不合规仍然是一个重大的全球公共卫生问题,破坏疾病控制工作并导致不良的临床和流行病学结果。虽然对这一问题进行了大量研究,但在了解不遵守的多因素影响,特别是其关键因素和影响以及加剧这些挑战的相互联系方面仍然存在差距。本研究整合了叙述和文献计量方法,批判性地综合和可视化导致结核病治疗不依从性及其影响的因素。通过填补研究空白,本研究旨在为理解多因素挑战提供一个全面的框架,并提出循证战略,以解决临床和流行病学问题。方法:系统检索Scopus, EBSCO (Medline), ScienceDirect和PubMed数据库,确定截至2024年12月发表的实证研究。主题综合将因素分类为总体主题,而使用VOSviewer软件的文献计量分析将因素及其相互联系可视化。结果:该综述确定了关键因素,如结核病知识贫乏、耻辱感、副作用和经济限制,并与人口、心理和系统障碍相互作用。网络可视化强调了这些因素之间的相互联系,说明了它们是如何结合起来加剧不合规的。临床和流行病学影响包括耐多药/广泛耐药结核病、长期治疗和社区传播。结论:结核病治疗不依从性是由个人、社会经济和卫生保健相关因素的复杂相互作用引起的。这篇综述强调了综合叙述和文献计量方法的重要性,以制定针对具体情况的策略,以提高依从性,减少全球结核病负担,并指导未来的研究和政策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
23
审稿时长
>12 weeks
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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