[Research progress on predictive indicators of a clinical cure for chronic hepatitis B].

Q3 Medicine
R Y Zhang, W Yue, L Zhu, J B Luo, B Bu, Y L Wang, Y M Wang, J W Geng
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引用次数: 0

Abstract

Nucleotide analogues (NAs) and interferon are still the first-line drugs for the treatment of chronic hepatitis B (CHB), but they still cannot completely eliminate covalently closed circular DNA (cccDNA) within hepatocytes. The clinical cure, or the disappearance of HBsAg, is the ideal goal of antiviral therapy. Although interferon therapy has a significantly greater HBsAg clearance rate and seroconversion rate than NAs, combination or sequential treatment can improve the HBsAg clearance rate and seroconversion rate to a certain extent, and only a small proportion of CHB patients can achieve clinical cure. Therefore, finding indications that predict clinical cure before and during antiviral treatment is crucial for identifying patients who are more likely to achieve HBsAg clearance at an early stage, improving clinical cure rates, and reducing treatment costs. This article reviews the research progress on predictive indicators of clinical cure of chronic hepatitis B in the past five years, explores the value of each indicator in predicting clinical cure, and provides a reference for optimizing CHB treatment strategies.

慢性乙型肝炎临床治愈预测因素的研究进展
虽然核苷酸类似物(NAs)和干扰素目前是慢性乙型肝炎的主要治疗方法,但它们并不能完全去除肝细胞中的cccDNA。抗病毒治疗的预期结果是缺乏乙型肝炎表面抗原(HBsAg),通常被称为临床治愈。虽然干扰素治疗的HBsAg清除率和血清学转换率明显高于NAs,但联合或顺序治疗可在一定程度上提高HBsAg清除率和血清学转换率。然而,只有一小部分患者能够获得临床治愈。因此,探索在抗病毒药物治疗前和治疗过程中可能预测临床治愈的适应症至关重要,这可以使早期和及时识别更有可能实现HBsAg清除的患者,提高临床治愈率,降低治疗费用。本文就近年来慢性乙型肝炎临床治愈预测指标的研究进展进行综述,并探讨其在预测临床治愈中的价值,为优化慢性乙型肝炎治疗策略提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
期刊介绍:
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