{"title":"Recombinant DNA: unlocking untapped microbial potential for innovation in crop agriculture.","authors":"Aranksha Thakor, Trevor C Charles","doi":"10.1016/j.tibtech.2025.01.001","DOIUrl":null,"url":null,"abstract":"<p><p>The Asilomar Conference on Recombinant DNA, held in 1975, established guidelines for recombinant DNA (rDNA) research and laid the foundation for biotechnology regulations. While rDNA has driven significant advancements in pharmaceutical and crop biotechnology, the commercialization of plant-beneficial microbials developed using rDNA has lagged behind. This disparity may be attributed to a cumbersome regulatory framework shaped by the perception that rDNA products pose biosafety risks. To unlock the full potential of rDNA technology in addressing global challenges, regulatory reform for rDNA-derived microbial products for crop plants that reduce reliance on chemical fertilizers and pesticides is essential. Streamlining these barriers will enable greater societal benefits from microbial solutions in agriculture and beyond.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":"43 3","pages":"533-539"},"PeriodicalIF":14.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2025.01.001","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The Asilomar Conference on Recombinant DNA, held in 1975, established guidelines for recombinant DNA (rDNA) research and laid the foundation for biotechnology regulations. While rDNA has driven significant advancements in pharmaceutical and crop biotechnology, the commercialization of plant-beneficial microbials developed using rDNA has lagged behind. This disparity may be attributed to a cumbersome regulatory framework shaped by the perception that rDNA products pose biosafety risks. To unlock the full potential of rDNA technology in addressing global challenges, regulatory reform for rDNA-derived microbial products for crop plants that reduce reliance on chemical fertilizers and pesticides is essential. Streamlining these barriers will enable greater societal benefits from microbial solutions in agriculture and beyond.
期刊介绍：
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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