Hiroyuki Takahashi, Yunchan Hwang, Jungeun Won, Muhammad Usman Jamil, Antonio Yaghy, Michelle C Liang, Caroline R Baumal, Andre J Witkin, Kyoko Ohno-Matsui, Jay S Duker, James G Fujimoto, Nadia K Waheed
{"title":"Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA.","authors":"Hiroyuki Takahashi, Yunchan Hwang, Jungeun Won, Muhammad Usman Jamil, Antonio Yaghy, Michelle C Liang, Caroline R Baumal, Andre J Witkin, Kyoko Ohno-Matsui, Jay S Duker, James G Fujimoto, Nadia K Waheed","doi":"10.1167/tvst.14.2.27","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To quantify the blood flow speed within retinal microaneurysms (MAs) and investigate the relationship between blood flow speed and clinical characteristics in eyes with diabetic retinopathy (DR).</p><p><strong>Methods: </strong>Variable interscan time analysis (VISTA) quantifies blood flow speed in the vasculature by measuring how fast optical coherence tomography (OCT) angiography (OCTA) saturates for different interscan times. Macular OCTA imaging was performed in eyes with DR using a high-speed swept-source OCT prototype instrument operating at a 600-kHz A-scan rate. The presence of MAs was determined using OCT B-scans, and three-dimensional MA masks were generated. VISTA flow speed (VFS) was determined within MAs and the retinal capillary plexus (RCP). Intraluminal reflectivity, axial location within the RCP, and the presence of intraretinal fluid (IRF) around the MAs were evaluated.</p><p><strong>Results: </strong>A total of 123 MAs were detected from 24 eyes of 20 patients with DR. Mean VFS was 1.26 ms-1 (95% confidence interval, 1.16-1.35). MAs with medium and high intraluminal reflectivity had slower VFS than those with low intraluminal reflectivity (P < 0.01) and often had slower VFS than the RCP (P < 0.01). Sixty-six MAs were located near IRF and had slower VFS than the other 57 MAs without surrounding IRF (1.16 ms-1 vs. 1.37 ms-1; P = 0.03).</p><p><strong>Conclusions: </strong>VISTA OCTA can assess blood flow speed of MAs in relation to other structural features in DR. Decreased blood flow speed in MAs is correlated with the presence of IRF around MAs.</p><p><strong>Translational relevance: </strong>We offer a new method that quantifies the blood flow speed of MAs to study the development of diabetic macular edema.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 2","pages":"27"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.2.27","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To quantify the blood flow speed within retinal microaneurysms (MAs) and investigate the relationship between blood flow speed and clinical characteristics in eyes with diabetic retinopathy (DR).
Methods: Variable interscan time analysis (VISTA) quantifies blood flow speed in the vasculature by measuring how fast optical coherence tomography (OCT) angiography (OCTA) saturates for different interscan times. Macular OCTA imaging was performed in eyes with DR using a high-speed swept-source OCT prototype instrument operating at a 600-kHz A-scan rate. The presence of MAs was determined using OCT B-scans, and three-dimensional MA masks were generated. VISTA flow speed (VFS) was determined within MAs and the retinal capillary plexus (RCP). Intraluminal reflectivity, axial location within the RCP, and the presence of intraretinal fluid (IRF) around the MAs were evaluated.
Results: A total of 123 MAs were detected from 24 eyes of 20 patients with DR. Mean VFS was 1.26 ms-1 (95% confidence interval, 1.16-1.35). MAs with medium and high intraluminal reflectivity had slower VFS than those with low intraluminal reflectivity (P < 0.01) and often had slower VFS than the RCP (P < 0.01). Sixty-six MAs were located near IRF and had slower VFS than the other 57 MAs without surrounding IRF (1.16 ms-1 vs. 1.37 ms-1; P = 0.03).
Conclusions: VISTA OCTA can assess blood flow speed of MAs in relation to other structural features in DR. Decreased blood flow speed in MAs is correlated with the presence of IRF around MAs.
Translational relevance: We offer a new method that quantifies the blood flow speed of MAs to study the development of diabetic macular edema.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
