SIRT7 Expression Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma Undergoing Postoperative Platinum-Based Adjuvant Chemotherapy.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urologia Internationalis Pub Date : 2025-02-27 DOI:10.1159/000544698

Yudong Cao, Jinchao Ma, Shuo Wang, Xiao Yang, Mengping Long, Yongpeng Ji, Ziyi Yu, Ruijian You, Chen Lin, Yong Yang, Peng Du

{"title":"SIRT7 Expression Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma Undergoing Postoperative Platinum-Based Adjuvant Chemotherapy.","authors":"Yudong Cao, Jinchao Ma, Shuo Wang, Xiao Yang, Mengping Long, Yongpeng Ji, Ziyi Yu, Ruijian You, Chen Lin, Yong Yang, Peng Du","doi":"10.1159/000544698","DOIUrl":null,"url":null,"abstract":"Introduction: The aim of this study was to evaluate the expression of SIRT7 in upper tract urothelial carcinoma (UTUC) as well as the predictive value for prognosis in patients undergoing radical nephroureterectomy followed platinum-based adjuvant chemotherapy.Methods: Pathological samples of 146 UTUC with clinical stage T2 and above undergoing radical nephrectomy (RNU) were collected. All patients received adjuvant cisplatin-based chemotherapy and 40 UTUC patients received second-line immunotherapy after disease progression. The relationship between the expression level of SIRT7 by immunohistochemistry and clinicopathological characteristics, disease-free survival (DFS), overall survival (OS), and OS after progression (POS) was analyzed.Results: Over a mean follow-up 47 months, 61 (41.8%) patients experienced recurrence and 42 (28.8%) patients died due to UTUC. The results revealed that 70.2% of UTUC tissue samples exhibited high expression levels of SIRT7. High expression of SIRT7 is associated with lymph node metastasis (p < 0.001), lymphovascular invasion (p = 0.001), and histological differentiation (p = 0.025). In addition, UTUC patients with elevated SIRT7 expression experienced significantly shorter DFS (hazard ratio [HR] 3.760, 95% CI: 1.884-7.504, p < 0.001 and OS (HR 2.706, 95% CI: 1.235-5.929, p = 0.013). Multivariate analyses demonstrated that SIRT7 served as a significant predictor for DFS (HR 2.337, 95% CI: 1.117-4.890, p = 0.024) in UTUC patients. Furthermore, we found SIRT7 high expression is associated with prolonged POS in patients progressed after adjuvant cisplatin-based chemotherapy and received second-line immunotherapy.Conclusion: SIRT7 is an independent prognostic marker of poor DFS in locally advanced UTUC patients after RNU. Moreover, these data suggest that SIRT7 could potentially serve as a target for assessing the efficacy of chemotherapy and immunotherapy in UTUC.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urologia Internationalis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000544698","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: The aim of this study was to evaluate the expression of SIRT7 in upper tract urothelial carcinoma (UTUC) as well as the predictive value for prognosis in patients undergoing radical nephroureterectomy followed platinum-based adjuvant chemotherapy.

Methods: Pathological samples of 146 UTUC with clinical stage T2 and above undergoing radical nephrectomy (RNU) were collected. All patients received adjuvant cisplatin-based chemotherapy and 40 UTUC patients received second-line immunotherapy after disease progression. The relationship between the expression level of SIRT7 by immunohistochemistry and clinicopathological characteristics, disease-free survival (DFS), overall survival (OS), and OS after progression (POS) was analyzed.

Results: Over a mean follow-up 47 months, 61 (41.8%) patients experienced recurrence and 42 (28.8%) patients died due to UTUC. The results revealed that 70.2% of UTUC tissue samples exhibited high expression levels of SIRT7. High expression of SIRT7 is associated with lymph node metastasis (p < 0.001), lymphovascular invasion (p = 0.001), and histological differentiation (p = 0.025). In addition, UTUC patients with elevated SIRT7 expression experienced significantly shorter DFS (hazard ratio [HR] 3.760, 95% CI: 1.884-7.504, p < 0.001 and OS (HR 2.706, 95% CI: 1.235-5.929, p = 0.013). Multivariate analyses demonstrated that SIRT7 served as a significant predictor for DFS (HR 2.337, 95% CI: 1.117-4.890, p = 0.024) in UTUC patients. Furthermore, we found SIRT7 high expression is associated with prolonged POS in patients progressed after adjuvant cisplatin-based chemotherapy and received second-line immunotherapy.

Conclusion: SIRT7 is an independent prognostic marker of poor DFS in locally advanced UTUC patients after RNU. Moreover, these data suggest that SIRT7 could potentially serve as a target for assessing the efficacy of chemotherapy and immunotherapy in UTUC.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.