Effects of home-use transcranial direct current stimulation on clusters of depressive symptoms: an ancillary analysis of the PSYLECT study.

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2025-02-27 DOI:10.47626/1516-4446-2024-3972

Matthias S Luethi, Lucas Borrione, Beatriz A Cavendish, Luana V M Aparicio, Stephan Goerigk, Matheus R F Ramos, Natasha K S Moran, Adriana M Carneiro, Leandro Valiengo, Darin O Moura, Juliana P de Souza, Mariana P Batista, Valquiria Aparecida da Silva, Izio Klein, Paulo Suen, José Gallucci-Neto, Frank Padberg, Lais B Razza, Marie-Anne Vanderhasselt, Paulo A Lotufo, Isabela M Bensenor, Felipe Fregni, Andre R Brunoni

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引用次数: 0

Abstract

Objective: Major depressive disorder (MDD) is heterogeneous. While transcranial direct current stimulation (tDCS) is an effective treatment, its impact on symptoms remains underexplored. This ancillary study investigated home-use tDCS effects on depression symptom clusters.

Methods: Data were from the Psylect study, where 210 depressed patients were randomized to active (n = 137) or sham tDCS (n = 73) for six weeks. Items from the Hamilton Depression Rating Scale were grouped into symptom clusters using hierarchical clustering. Treatment effects were analyzed with mixed regressions. An alternative clustering solution, established with a bigger sample, was also evaluated.

Results: Four clusters were identified: emotional, sleep, psychomotor, and psychosomatic symptoms. None showed significant group differences (sleep: P = 0.058, Cohen's d = 0.36, emotional: P = 0.976, d = -0.01, psychosomatic: P = 0.157, d = 0.27, psychomotor: P = 0.944, d = 0.01). The alternative clustering solution produced a similar sleep cluster, where tDCS led to significant reductions (P = 0.033, d = 0.41), while other clusters exhibited no differences (emotional: P = 0.707, d = 0.07, atypical: p = 0.537, d = 0.12).

Conclusions: Associations of tDCS with sleep improvements warrant further study. tDCS may be more effective for specific symptom clusters.

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家用经颅直流电刺激对抑郁症状簇的影响：PSYLECT研究的辅助分析

目的：重度抑郁障碍（MDD）具有异质性。虽然经颅直流电刺激（tDCS）是一种有效的治疗方法，但其对症状的影响仍未得到充分探讨。本辅助研究调查了家用tDCS对抑郁症状群的影响。方法：数据来自Psylect研究，其中210名抑郁症患者被随机分为主动（n = 137）或假性tDCS （n = 73）组，为期6周。采用分层聚类法将汉密尔顿抑郁评定量表的条目分为症状类。采用混合回归分析治疗效果。还评估了使用更大样本建立的另一种聚类解决方案。结果：确定了四类症状：情绪、睡眠、精神运动和心身症状。各组间差异均无统计学意义（睡眠：P = 0.058, Cohen’s d = 0.36，情绪：P = 0.976, d = -0.01，心身：P = 0.157, d = 0.27，精神运动：P = 0.944, d = 0.01）。替代聚类方案产生了类似的睡眠聚类，其中tDCS导致显著减少（P = 0.033, d = 0.41），而其他聚类没有表现出差异（情感：P = 0.707, d = 0.07，非典型：P = 0.537, d = 0.12）。结论：tDCS与睡眠改善的关系值得进一步研究。tDCS可能对特定症状群更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.