Rate of vertical transmission of coronavirus disease 2019 and effect of maternal vaccination: A prospective cohort study.

IF 1 4区 医学 Q3 PEDIATRICS
Satoshi Matsunashi, Hiroyuki Unoki-Kubota, Takehiro Sugiyama, Kei Yamamoto, Shinsuke Ebihara, Nobuko Nishioka, Kaoru Okazaki, Izumi Honda, Kohei Kashima, Hiroko Arai, Yayoi Murano, Ichiro Morioka, Miyuki Sadatsuki, Hajime Oishi, Shinji Mochizuki, Yasushi Kaburagi, Hiroyuki Shichino, Fumihiko Namba, Norihiro Kato, Tomohisa Akamatsu
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引用次数: 0

Abstract

Background: We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID-19) and clinical features of congenital and neonatal COVID-19 and to disclose the efficacy of maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers and infants were enrolled and classified into an active infection group (mothers with COVID-19 at delivery), a postinfection group (mothers recovered from COVID-19 during pregnancy), and a vaccination group (mothers vaccinated during pregnancy). Specimen collections, polymerase chain reaction assays, anti-SARS-CoV-2 antibody measurements, and clinical examinations were conducted for 6 months from delivery.

Results: Sixty-nine mothers and 70 infants were enrolled. SARS-CoV-2 was detected in the placenta in 22% of the active infection group and in 21% of the postinfection group. Neither SARS-CoV-2 nor SARS-CoV-2-specific IgM was detected in infants. No anomalies, functional disorders, or developmental problems were observed in infants for 6 months. Compared with the postinfection group, there was a significant increase in maternally transferred antibody titers in the vaccination group according to the number of vaccinations, which was maintained for longer than the first month of life.

Conclusions: Vertical transmission of COVID-19 was not observed despite a comprehensive testing protocol. SARS-CoV-2 was detected more often in the placenta, which appeared to prevent vertical transmission. Maternal vaccination increased maternally transferred antibody titers in infants and was considered immunologically efficient. Vaccination during pregnancy is considered important for preventing congenital, neonatal, and infantile COVID-19.

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来源期刊
Pediatrics International
Pediatrics International 医学-小儿科
CiteScore
2.00
自引率
7.10%
发文量
519
审稿时长
12 months
期刊介绍: Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.
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