Andreas Radeloff, Katrin Radeloff, Rolf-Peter Henke, Sarah Hahnke, Maureen Loewenthal
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引用次数: 0
Abstract
Objective: To report a patient who was misdiagnosed and operated on for cerebrospinal fluid (CSF) otorrhea and to demonstrate that cholesterol granulomas mimic CSF leakage by secreting beta-trace protein (BTP).
Patients: Eleven consecutive patients undergoing ear surgery in whom cholesterol granulomas were discovered intraoperatively.
Intervention: Biochemical and histologic analysis of liquid and solid fractions of cholesterol granulomas.
Main outcome measures: BTP and beta-2-transferrin concentrations and BTP mRNA levels in surgical specimens.
Results: Cholesterol granulomas produce BTP and express high levels of BTP mRNA, but do not produce beta-2-transferrin.
Conclusions: Beta-2 transferrin analysis is preferable to BTP analysis for the detection of CSF otorrhea because BTP may be false positive in the presence of cholesterol granulomas.
期刊介绍：
Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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