Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI:10.1080/01616412.2025.2472836

Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran

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引用次数: 0

Abstract

Objective: Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).

Method: This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.

Result: No significant differences in NfL levels were observed between RLS patients and controls (p > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (p > 0.05).

Conclusion: These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.