A randomized crossover trial: The impact of ocular lubrication on migraine severity in persons with dry eye disease and migraine.

IF 1.8 4区医学 Q3 OPHTHALMOLOGY

Optometry and Vision Science Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI:10.1097/OPX.0000000000002241

Nur Amalina Md Isa, Arun V Krishnan, Alessandro S Zagami, Shyam S Tummanapalli, Katherine Spira, Eric B Papas, Azadeh Tavakoli, Maria Markoulli

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引用次数: 0

Abstract

Significance: Significant associations in the epidemiologic and clinical features between migraine and dry eye syndrome suggest that both conditions are comorbid. A potentially overlapping pathophysiological mechanism further indicates a connection between the two conditions. This study highlights the clinical implications of treating dry eye disease on migraine.

Purpose: This study aimed to investigate the impact on migraine severity of treating dry eye disease in migraine patients using ocular lubricants.

Methods: A randomized, double-masked, crossover trial was conducted on 24 participants with both migraine and dry eye disease. They received either Systane Hydration UD (Alcon, Fort Worth, TX) or saline eye drops (NeilMed, Santa Rosa, CA) four times per day for 4 weeks each, with a 2-week washout period between treatments. Migraine severity was assessed using the Headache Impact Test 6 (HIT-6) and Migraine Disability Assessment questionnaires. Dry eye disease was evaluated using the Ocular Surface Disease Index (OSDI), Dry Eye Questionnaire 5 (DEQ-5), tear breakup time, tear osmolarity, and corneal surface integrity. Outcomes were assessed at baseline and after using the first and then second drops.

Results: Ocular lubrication was significantly associated with reduced migraine severity and dry eye disease. The HIT-6 score was reduced from baseline when using Systane Hydration UD (mean change, ∆ = -3.0, p=0.01) and saline (∆ = -3.9, p=0.002). Dry eye disease symptoms and corneal staining were reduced when using Systane Hydration UD (OSDI ∆ = -8.3, p=0.004; DEQ-5 ∆ = -2.1, p=0.004; corneal staining ∆ = -2.2, p=0.001) and saline (OSDI ∆ = -6.4, p=0.03; DEQ-5 ∆ = -1.5, p=0.03; corneal staining ∆ = -1.5, p=0.005).

Conclusions: When migraine and dry eye disease coexist, successfully treating dry eye disease reduces the severity of migraine, as measured by HIT-6.

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一项随机交叉试验：眼润滑对干眼病和偏头痛患者偏头痛严重程度的影响。

意义：偏头痛和干眼综合征之间的流行病学和临床特征的显著关联表明这两种情况是共病。潜在重叠的病理生理机制进一步表明这两种情况之间存在联系。本研究强调了治疗偏头痛干眼病的临床意义。目的：本研究旨在探讨使用眼润滑剂治疗偏头痛患者干眼病对偏头痛严重程度的影响。方法：对24例偏头痛和干眼症患者进行随机、双盲、交叉试验。他们接受Systane Hydration UD （Alcon, Fort Worth， TX）或生理盐水滴眼液（NeilMed, Santa Rosa， CA），每天4次，每次4周，两次治疗之间有2周的洗脱期。使用头痛影响测试6 （HIT-6）和偏头痛残疾评估问卷评估偏头痛严重程度。采用眼表疾病指数（OSDI）、干眼问卷5 （DEQ-5）、泪液破裂时间、泪液渗透压和角膜表面完整性评估干眼病。在基线和使用第一次和第二次滴药后评估结果。结果：眼润滑与减轻偏头痛严重程度和干眼症显著相关。使用Systane Hydration UD（平均变化，∆= -3.0,p=0.01）和生理盐水（∆= -3.9,p=0.002）时，HIT-6评分较基线降低。使用Systane Hydration UD （OSDI∆= -8.3,p=0.004）可减少干眼病症状和角膜染色；DEQ-5∆= -2.1,p=0.004；角膜染色∆= -2.2,p=0.001)和生理盐水(OSDI∆= -6.4,p=0.03；DEQ-5∆= -1.5,p=0.03；角膜染色∆= -1.5,p=0.005)。结论：当偏头痛和干眼病共存时，成功治疗干眼病可以降低偏头痛的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optometry and Vision Science 医学-眼科学

CiteScore

2.80

自引率

7.10%

发文量

210

审稿时长

3-6 weeks

期刊介绍： Optometry and Vision Science is the monthly peer-reviewed scientific publication of the American Academy of Optometry, publishing original research since 1924. Optometry and Vision Science is an internationally recognized source for education and information on current discoveries in optometry, physiological optics, vision science, and related fields. The journal considers original contributions that advance clinical practice, vision science, and public health. Authors should remember that the journal reaches readers worldwide and their submissions should be relevant and of interest to a broad audience. Topical priorities include, but are not limited to: clinical and laboratory research, evidence-based reviews, contact lenses, ocular growth and refractive error development, eye movements, visual function and perception, biology of the eye and ocular disease, epidemiology and public health, biomedical optics and instrumentation, novel and important clinical observations and treatments, and optometric education.