Sagittal Cephalometric Characteristics in Females With Turner Syndrome in Comparison to Nonsyndromic Females: A Meta-Analysis.

IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Kara Bierley, Gregory S Antonarakis
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引用次数: 0

Abstract

The present study aimed to assess the sagittal cephalometric characteristics in females with Turner syndrome (TS) as compared with nonsyndromic females. A literature search was carried out using six electronic databases to identify studies that compared the sagittal lateral cephalometric measurements in females with TS, with the last search performed in February 2024. Studies were selected according to the following inclusion criteria: an experimental group of individuals with TS compared to a control group of females without TS; with sagittal cephalometric characteristics evaluated on lateral cephalometric radiographs. Sagittal cephalometric variables measured in three or more studies were put to meta-analysis, using the random-effects model. Subgroup meta-analyses were also carried out based on karyotype. A modified version of the AXIS tool was used to assess the risk of bias in the included studies. From the initial 199 records identified, 17 studies and 11 sagittal cephalometric variablesere analysed. Four hundred and seventeen unique patients with TS, coming from 10 different European countries, were included. All of the sagittal linear variables compared, namely S-N, N-Ba, Go-Gn, Go-Pg and ANS-PNS, were significantly reduced in those with TS. Concerning the six angular variables compared, the A-N-B angle showed no difference between the groups, whereas the S-N-A, S-N-B and S-N-Pg angles were significantly reduced, and the N-S-Ba and the N-S-Ar angles significantly increased in those with TS. The subgroup meta-analyses for karyotype consistently revealed mean differences much greater than the norm for the 45,X karyotype group than those of the mosaic and isochromosome karyotypes. The sagittal lateral cephalometric characteristics of females with TS differ significantly from those of nonsyndromic females, with the greatest deviation from the norm displayed in the 45,X karyotype. Bimaxillary retrognathia and reduced anterior cranial base and maxillary and mandibular lengths were observed, without this resulting, however, in any difference with regard to the sagittal intermaxillary relationships for the females with TS. While informative, the results of this meta-analysis should be considered in conjunction with the respective risk of bias of each study, as most studies rated towards the moderate to high end of the spectrum. Trial Registration: This study was registered in PROSPERO on September 22, 2022, with the ID CRD42022356773.

特纳综合征女性与非特纳综合征女性的头颅矢状面特征比较:元分析。
本研究旨在评估特纳综合征(TS)女性与非综合征女性的矢状面测量特征。使用6个电子数据库进行文献检索,以确定与2024年2月进行的最后一次检索相比,女性TS患者矢状位侧位头测量的研究。根据以下纳入标准选择研究:实验组为患有TS的个体,对照组为无TS的女性;在侧位头颅x线片上评估矢状面特征。在三个或更多的研究中测量的矢状头测量变量使用随机效应模型进行荟萃分析。还根据核型进行了亚组荟萃分析。使用改良版的AXIS工具评估纳入研究的偏倚风险。从最初确定的199个记录中,分析了17个研究和11个矢状位测量变量。来自10个不同欧洲国家的417名独特的TS患者被纳入研究。S-N、N-Ba、Go-Gn、Go-Pg和ANS-PNS的矢状面线性变量在TS组中均显著降低,在6个角度变量中,A-N-B角度组间无差异,S-N- a、S-N- b和S-N- pg角度组间显著降低。N-S-Ba角和N-S-Ar角在TS组显著增加。核型亚群荟萃分析一致显示,45,X核型组的平均差异远大于马赛克和同染色体核型组的平均值。患有TS的女性矢状位侧位测量特征与无综合征女性有显著差异,与45x核型的正常值偏差最大。观察到双颌后突、前颅底、上颌和下颌骨长度减少,但在女性TS患者的矢状面上颌间关系方面没有任何差异。虽然信息丰富,但本荟萃分析的结果应与每个研究各自的偏倚风险一并考虑,因为大多数研究的评分都在光谱的中至高端。试验注册:本研究于2022年9月22日在普洛斯彼罗注册,编号CRD42022356773。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Orthodontics & Craniofacial Research
Orthodontics & Craniofacial Research 医学-牙科与口腔外科
CiteScore
5.30
自引率
3.20%
发文量
65
审稿时长
>12 weeks
期刊介绍: Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions. The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements. The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.
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