Fouling process of hemodiafiltration membranes by hemodialysis and hemodiafiltration therapy.

IF 1.1 4区医学 Q4 ENGINEERING, BIOMEDICAL

Journal of Artificial Organs Pub Date : 2025-02-27 DOI:10.1007/s10047-025-01497-9

Yoshihiro Tange, Masashi Kawakami, Shingo Takesawa

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引用次数: 0

Abstract

During hemodialysis, proteins, such as albumin and globulin, are deposited on the dialysis membrane surface, causing fouling that affects solute removal and biocompatibility. This study aimed to measure the filtration coefficient as an index of dialysis membrane conditions in hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration modes using two different hemodiafiltration membranes ex vivo. The filtration coefficients of hemodiafiltration membranes in hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration modes were continuously measured for 123 min using 2 L bovine blood, which was adjusted with 32% hematocrit and 6.5 g/dL of total proteins. Polysulfone and cellulose triacetate were used as test membrane materials, and both membrane structures were asymmetric. The first fouling step was observed 20 s after filtration of both polysulfone and cellulose triacetate membranes in each mode. Thereafter, the filtration coefficient recovered in the pre-dilution online hemodiafiltration mode. However, it plateaued in the cellulose triacetate membrane and decreased in the polysulfone membrane. A flushing effect of the intermittent infusion hemodiafiltration mode was observed in both the cellulose triacetate and polysulfone membranes. The differences in fouling steps in each of the three modes-hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration-can be identified by continuously measuring filtration coefficient values.

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血液透析及血液滤过治疗对血液滤过膜的污染过程。

在血液透析过程中，蛋白质，如白蛋白和球蛋白，沉积在透析膜表面，造成污染，影响溶质的去除和生物相容性。本研究旨在体外测量两种不同血液滤膜在血液透析、预稀释在线血液滤膜和间歇输注血液滤膜模式下的过滤系数作为透析膜状况的指标。采用2 L牛血，以32%的红细胞比容和6.5 g/dL的总蛋白为调节因子，连续测量血液透析、预稀释在线血液滤过和间歇输注血液滤过模式下血液滤过膜的滤过系数123 min。以聚砜和三醋酸纤维素为试验膜材料，两种膜结构均为不对称膜。聚砜膜和三醋酸纤维素膜在每种模式下过滤20 s后观察到第一个污染步骤。之后，过滤系数在预稀释在线血液滤过模式下恢复。然而，它在三醋酸纤维素膜中趋于稳定，在聚砜膜中下降。在三醋酸纤维素膜和聚砜膜中观察到间歇输注血液滤过方式的冲洗效果。通过连续测量过滤系数值，可以确定三种模式（血液透析、预稀释在线血液滤过和间歇输注血液滤过）中污垢步骤的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Artificial Organs 医学-工程：生物医学

CiteScore

2.80

自引率

15.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.