Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial.

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Journal of applied physiology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI:10.1152/japplphysiol.01024.2024
Benjamin J Ryan, Thomas A Mayer, Billie K Alba, Karleigh E Bradbury, Shaun C Brazelton, Nisha Charkoudian, K Riley Connor, Benjamin A Fry, Gabrielle E W Giersch, Rachel A Gioscia-Ryan, Andrew M Greenfield, Harris R Lieberman, Afton D Seeley, John H Sellers, Joseph D Shevchik, Jesse A Stein, Erik R Swenson, Roy M Salgado
{"title":"Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial.","authors":"Benjamin J Ryan, Thomas A Mayer, Billie K Alba, Karleigh E Bradbury, Shaun C Brazelton, Nisha Charkoudian, K Riley Connor, Benjamin A Fry, Gabrielle E W Giersch, Rachel A Gioscia-Ryan, Andrew M Greenfield, Harris R Lieberman, Afton D Seeley, John H Sellers, Joseph D Shevchik, Jesse A Stein, Erik R Swenson, Roy M Salgado","doi":"10.1152/japplphysiol.01024.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Exposure to elevated inspired carbon dioxide (CO<sub>2</sub>) levels, an environmental threat in several occupational settings, is known to induce systemic hypercapnia and provoke headache. However, the impact of CO<sub>2</sub> exposure dose on headache severity has not been determined, and countermeasures to mitigate systemic hypercapnia and headache during CO<sub>2</sub> exposure are lacking. In this study, we first characterized respiratory responses and headache with graded CO<sub>2</sub> exposure (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO<sub>2</sub>, all with 21% oxygen) during seated rest in 24 healthy males and females. As expected, graded CO<sub>2</sub> exposure resulted in stepwise increases (41 ± 3, 43 ± 2, 46 ± 2, 53 ± 2, 65 ± 1 mmHg; <i>P</i> < 0.001) in end-tidal CO<sub>2</sub> across the spectrum from normocapnia to severe hypercapnia. Headache increased (<i>P</i> < 0.05) beginning at 4% inspired CO<sub>2</sub> (1 ± 2, 2 ± 3, 8 ± 8, 16 ± 13, 32 ± 20 mm on a 100-mm visual analog scale). Participants then completed the same graded CO<sub>2</sub> exposure 1 h following either caffeine (400 mg) or placebo supplementation in a randomized, double-blind, crossover manner (<i>n</i> = 23). Caffeine increased ventilation and lowered end-tidal CO<sub>2</sub> at inspired CO<sub>2</sub> levels between 0% and 6% (<i>P</i> < 0.05), corresponding with a leftward shift in the end-tidal CO<sub>2</sub>-ventilation response curve with unchanged slope. Caffeine substantially reduced headache during graded CO<sub>2</sub> exposure, an effect that was most pronounced at 8% inspired CO<sub>2</sub> (placebo: 25 ± 15 mm, caffeine: 13 ± 12 mm; <i>P</i> < 0.05). Our novel findings establish prophylactic caffeine supplementation as a translational countermeasure to mitigate systemic hypercapnia and headache during CO<sub>2</sub> exposure.<b>NEW & NOTEWORTHY</b> In this study, we first characterized systemic hypercapnia and headache severity during graded CO<sub>2</sub> exposures (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO<sub>2</sub>). Using a randomized, double-blind, crossover trial, we then showed that prophylactic treatment with 400 mg caffeine mitigates systemic hypercapnia and headache during graded CO<sub>2</sub> exposure. Overall, these novel findings establish caffeine as the first evidence-based countermeasure to mitigate adverse effects associated with CO<sub>2</sub> exposure.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"881-890"},"PeriodicalIF":3.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.01024.2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Exposure to elevated inspired carbon dioxide (CO2) levels, an environmental threat in several occupational settings, is known to induce systemic hypercapnia and provoke headache. However, the impact of CO2 exposure dose on headache severity has not been determined, and countermeasures to mitigate systemic hypercapnia and headache during CO2 exposure are lacking. In this study, we first characterized respiratory responses and headache with graded CO2 exposure (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO2, all with 21% oxygen) during seated rest in 24 healthy males and females. As expected, graded CO2 exposure resulted in stepwise increases (41 ± 3, 43 ± 2, 46 ± 2, 53 ± 2, 65 ± 1 mmHg; P < 0.001) in end-tidal CO2 across the spectrum from normocapnia to severe hypercapnia. Headache increased (P < 0.05) beginning at 4% inspired CO2 (1 ± 2, 2 ± 3, 8 ± 8, 16 ± 13, 32 ± 20 mm on a 100-mm visual analog scale). Participants then completed the same graded CO2 exposure 1 h following either caffeine (400 mg) or placebo supplementation in a randomized, double-blind, crossover manner (n = 23). Caffeine increased ventilation and lowered end-tidal CO2 at inspired CO2 levels between 0% and 6% (P < 0.05), corresponding with a leftward shift in the end-tidal CO2-ventilation response curve with unchanged slope. Caffeine substantially reduced headache during graded CO2 exposure, an effect that was most pronounced at 8% inspired CO2 (placebo: 25 ± 15 mm, caffeine: 13 ± 12 mm; P < 0.05). Our novel findings establish prophylactic caffeine supplementation as a translational countermeasure to mitigate systemic hypercapnia and headache during CO2 exposure.NEW & NOTEWORTHY In this study, we first characterized systemic hypercapnia and headache severity during graded CO2 exposures (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO2). Using a randomized, double-blind, crossover trial, we then showed that prophylactic treatment with 400 mg caffeine mitigates systemic hypercapnia and headache during graded CO2 exposure. Overall, these novel findings establish caffeine as the first evidence-based countermeasure to mitigate adverse effects associated with CO2 exposure.

众所周知,暴露于高浓度的二氧化碳(CO2)环境中会诱发全身性高碳酸血症并引发头痛。然而,二氧化碳暴露剂量对头痛严重程度的影响尚未确定,也缺乏在二氧化碳暴露期间减轻全身高碳酸血症和头痛的对策。在本研究中,我们首先描述了 24 名健康男性和女性在坐着休息时分级接触二氧化碳(0%、2%、4%、6% 和 8% 的二氧化碳吸入量,均为 21% 氧气,连续 12 分钟)时的呼吸反应和头痛特征。不出所料,分级二氧化碳暴露会导致从正常碳酸血症到严重高碳酸血症范围内的p2逐步上升(41±3、43±2、46±2、53±2、65±1 mmHg)。头痛加剧(p2(1±2、2±3、8±8、16±13、32±20 毫米,100 毫米视觉模拟量表)。然后,以随机、双盲、交叉的方式,在补充咖啡因(400 毫克)或安慰剂(n=23)1 小时后,参与者完成同样的二氧化碳分级暴露。在二氧化碳浓度为 0% 至 6% 的情况下,咖啡因可增加通气量并降低潮气末二氧化碳浓度(p2-通气反应曲线斜率不变)。咖啡因大大减轻了二氧化碳分级暴露时的头痛,这种效应在二氧化碳吸入量为 8% 时最为明显(安慰剂:25±15 mm,咖啡因:13±12 mm;p2 暴露。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信