CEL: A Continual Learning Model for Disease Outbreak Prediction by Leveraging Domain Adaptation via Elastic Weight Consolidation.

IF 3.9 2区 生物学 Q1 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Saba Aslam, Abdur Rasool, Xiaoli Li, Hongyan Wu
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引用次数: 0

Abstract

Continual learning is the ability of a model to learn over time without forgetting previous knowledge. Therefore, adapting new data in dynamic fields like disease outbreak prediction is paramount. Deep neural networks are prone to error due to catastrophic forgetting. This study introduces a novel CEL model for Continual Learning by leveraging domain adaptation via Elastic weight consolidation (EWC). This model aims to mitigate the catastrophic forgetting phenomenon in a domain incremental setting. The Fisher information matrix (FIM) is constructed with EWC to develop a regularization term that penalizes changes to essential parameters. We conducted experiments on three distinct diseases, influenza, mpox, and measles, with customized metrics. The high R-squared values during evaluation and reevaluation outperform the other state-of-the-art models in several contexts. The results indicate that CEL adapts well to incremental data. CEL's robustness emphasizes its minimal 65% forgetting rate and 18% higher memory stability compared to existing benchmark studies. This study highlights CEL's versatility in disease outbreak prediction by addressing evolving data with temporal patterns. It offers a valuable model for proactive disease control with accurate and timely predictions.

CEL:通过弹性权重整合利用领域适应的疾病爆发预测的持续学习模型。
持续学习是模型在不忘记先前知识的情况下随时间学习的能力。因此,在疾病爆发预测等动态领域采用新数据至关重要。由于灾难性遗忘,深度神经网络容易出错。本研究引入了一种新的CEL模型,通过弹性权重巩固(EWC)利用领域适应进行持续学习。该模型旨在减轻领域增量设置下的灾难性遗忘现象。利用EWC构造Fisher信息矩阵(FIM),建立一个正则化项来惩罚基本参数的变化。我们对三种不同的疾病——流感、痘和麻疹——进行了实验,并采用了定制的指标。在评估和再评估期间的高r平方值在某些情况下优于其他最先进的模型。结果表明,CEL对增量数据具有较好的适应性。与现有的基准研究相比,CEL的稳健性强调其最低65%的遗忘率和18%的记忆稳定性。这项研究强调了CEL在疾病爆发预测中的多功能性,通过处理具有时间模式的不断变化的数据。它提供了一个具有准确和及时预测的前瞻性疾病控制的有价值的模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Interdisciplinary Sciences: Computational Life Sciences
Interdisciplinary Sciences: Computational Life Sciences MATHEMATICAL & COMPUTATIONAL BIOLOGY-
CiteScore
8.60
自引率
4.20%
发文量
55
期刊介绍: Interdisciplinary Sciences--Computational Life Sciences aims to cover the most recent and outstanding developments in interdisciplinary areas of sciences, especially focusing on computational life sciences, an area that is enjoying rapid development at the forefront of scientific research and technology. The journal publishes original papers of significant general interest covering recent research and developments. Articles will be published rapidly by taking full advantage of internet technology for online submission and peer-reviewing of manuscripts, and then by publishing OnlineFirstTM through SpringerLink even before the issue is built or sent to the printer. The editorial board consists of many leading scientists with international reputation, among others, Luc Montagnier (UNESCO, France), Dennis Salahub (University of Calgary, Canada), Weitao Yang (Duke University, USA). Prof. Dongqing Wei at the Shanghai Jiatong University is appointed as the editor-in-chief; he made important contributions in bioinformatics and computational physics and is best known for his ground-breaking works on the theory of ferroelectric liquids. With the help from a team of associate editors and the editorial board, an international journal with sound reputation shall be created.
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