{"title":"CEL: A Continual Learning Model for Disease Outbreak Prediction by Leveraging Domain Adaptation via Elastic Weight Consolidation.","authors":"Saba Aslam, Abdur Rasool, Xiaoli Li, Hongyan Wu","doi":"10.1007/s12539-024-00675-2","DOIUrl":null,"url":null,"abstract":"<p><p>Continual learning is the ability of a model to learn over time without forgetting previous knowledge. Therefore, adapting new data in dynamic fields like disease outbreak prediction is paramount. Deep neural networks are prone to error due to catastrophic forgetting. This study introduces a novel CEL model for Continual Learning by leveraging domain adaptation via Elastic weight consolidation (EWC). This model aims to mitigate the catastrophic forgetting phenomenon in a domain incremental setting. The Fisher information matrix (FIM) is constructed with EWC to develop a regularization term that penalizes changes to essential parameters. We conducted experiments on three distinct diseases, influenza, mpox, and measles, with customized metrics. The high R-squared values during evaluation and reevaluation outperform the other state-of-the-art models in several contexts. The results indicate that CEL adapts well to incremental data. CEL's robustness emphasizes its minimal 65% forgetting rate and 18% higher memory stability compared to existing benchmark studies. This study highlights CEL's versatility in disease outbreak prediction by addressing evolving data with temporal patterns. It offers a valuable model for proactive disease control with accurate and timely predictions.</p>","PeriodicalId":13670,"journal":{"name":"Interdisciplinary Sciences: Computational Life Sciences","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary Sciences: Computational Life Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12539-024-00675-2","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Continual learning is the ability of a model to learn over time without forgetting previous knowledge. Therefore, adapting new data in dynamic fields like disease outbreak prediction is paramount. Deep neural networks are prone to error due to catastrophic forgetting. This study introduces a novel CEL model for Continual Learning by leveraging domain adaptation via Elastic weight consolidation (EWC). This model aims to mitigate the catastrophic forgetting phenomenon in a domain incremental setting. The Fisher information matrix (FIM) is constructed with EWC to develop a regularization term that penalizes changes to essential parameters. We conducted experiments on three distinct diseases, influenza, mpox, and measles, with customized metrics. The high R-squared values during evaluation and reevaluation outperform the other state-of-the-art models in several contexts. The results indicate that CEL adapts well to incremental data. CEL's robustness emphasizes its minimal 65% forgetting rate and 18% higher memory stability compared to existing benchmark studies. This study highlights CEL's versatility in disease outbreak prediction by addressing evolving data with temporal patterns. It offers a valuable model for proactive disease control with accurate and timely predictions.
期刊介绍:
Interdisciplinary Sciences--Computational Life Sciences aims to cover the most recent and outstanding developments in interdisciplinary areas of sciences, especially focusing on computational life sciences, an area that is enjoying rapid development at the forefront of scientific research and technology.
The journal publishes original papers of significant general interest covering recent research and developments. Articles will be published rapidly by taking full advantage of internet technology for online submission and peer-reviewing of manuscripts, and then by publishing OnlineFirstTM through SpringerLink even before the issue is built or sent to the printer.
The editorial board consists of many leading scientists with international reputation, among others, Luc Montagnier (UNESCO, France), Dennis Salahub (University of Calgary, Canada), Weitao Yang (Duke University, USA). Prof. Dongqing Wei at the Shanghai Jiatong University is appointed as the editor-in-chief; he made important contributions in bioinformatics and computational physics and is best known for his ground-breaking works on the theory of ferroelectric liquids. With the help from a team of associate editors and the editorial board, an international journal with sound reputation shall be created.