Identifying Biomarkers of Neuroplasticity Associated with Exercise-Induced Cognitive Change in Older Adults with MCI.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY

Experimental Aging Research Pub Date : 2025-02-27 DOI:10.1080/0361073X.2025.2470579

Adriana Savettiere, Peter Louras, Sarah Langdon, J Kaci Fairchild

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引用次数: 0

Abstract

Objectives: This exploratory study aimed to identify biomarkers of neuroplasticity that prevent cognitive decline. This study examined activity-dependent changes in the neurologic proteome that contributed to post-exercise improvements in processing speed in older adults with mild cognitive impairment (MCI).

Methods: Participants included 20 older adult Veterans with MCI recruited through the VA Palo Alto Health Care System (VAPAHCS) who participated in moderate-high intensity water-based activity thrice weekly for six months. Plasma protein concentration was measured using the Olink Target 96 Neurology Assay. Processing speed measures included the Trail Making Test Trial A (TMT-A), the Stroop Color (SC) and Word (SW) trials, and the Symbol Digit Modalities Test (SDMT).

Results: Preliminary analyses revealed two proteins of interest: neuropilin-2 (NRP2) and neuroblastoma suppressor of tumorigenicity 1 (NBL1). Primary analyses used mixed effects models to determine the impact of changes in neurologic-related proteins on changes in processing speed after exercise. Results indicated that decreased levels of NRP2 were associated with improved outcomes on the SDMT after exercise. In contrast, changes in NBL1 had no significant effect on the relationship between exercise and processing speed.

Conclusion: These results support previous research linking NRP2 function to synaptic plasticity downscaling and present NRP2 as a potential target for cognitive intervention.

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来源期刊

Experimental Aging Research 医学-老年医学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.