Cardiovascular disease risk prediction and profiling among Asian Indians with young-onset type 1 and type 2 diabetes.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetic Medicine Pub Date : 2025-02-28 DOI:10.1111/dme.70020

Sengottuvelu Aswath Krishna, Ulagamathesan Venkatesan, Anandakumar Amutha, Saravanan Jebarani, Gunasekaran Sengottuvelu, Ranjit Unnikrishnan, Viswanathan Mohan, Ranjit Mohan Anjana

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引用次数: 0

Abstract

Aims: This study aims to describe the profile of Asian Indians with young-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) who have 'low cardiovascular disease (CVD) risk' and 'high CVD risk' based on QRESEARCH risk estimator version 3(QRISK3) and Framingham Risk Score (FRS). It also aims to assess the predictive ability of these risk calculators to estimate CVD risk in this population.

Methods: Retrospective data of 18,837 individuals with T1D or T2D with an age of onset of between 10 to 30 years were retrieved from Diabetes Electronic Medical Records. QRISK3 algorithm and FRS were used to estimate the 10-year risk of CVD. After excluding individuals with preexisting CVD (n = 175), the QRISK3 score was calculated for 5371, and FRS for 7444 individuals with young-onset T1D and T2D. CVD risk was categorized as high if the QRISK3 and FRS scores ≥10.0% and low, if <10.0%.

Results: Among individuals with T1D,17.3% had high QRISK3 scores and 19.0% had high FRS scores. Among individuals with T2D, 31.9% had high QRISK3 scores and 37.2% had high FRS scores. Individuals with T2D had a higher risk than those with T1D by both risk scores (p < 0.001). The frequency of high-risk scores increased with age and was higher among men. The receiver operating characteristic-area under the curve (ROC-AUC) showed that both scores (QRISK3-0.788; FRS-0.746; p = 0.241) predicted 10-year cardiovascular disease risk well.

Conclusion: Both QRISK and FRS were good predictors of CVD in this population. Individuals with young-onset diabetes have a high propensity to develop cardiovascular disease within 10 years, with T2D having a higher risk than T1D. Regular risk monitoring, lifestyle modifications and medical interventions are essential among individuals with young-onset T2D and T1D.

查看原文本刊更多论文

亚洲印度年轻发病1型和2型糖尿病患者的心血管疾病风险预测和分析

目的：本研究旨在描述基于QRESEARCH风险评估器版本3（QRISK3）和Framingham风险评分（FRS）的具有“低心血管疾病（CVD）风险”和“高心血管疾病风险”的年轻发病的1型糖尿病（T1D）和2型糖尿病（T2D）的亚洲印度人的概况。它还旨在评估这些风险计算器在估计该人群心血管疾病风险方面的预测能力。方法：从糖尿病电子病历中检索18837例发病年龄在10 - 30岁之间的T1D或T2D患者的回顾性数据。采用QRISK3算法和FRS估计10年心血管疾病风险。在排除既往存在CVD的个体（n = 175）后，计算5371例的QRISK3评分和7444例年轻发病的T1D和T2D患者的FRS。如果QRISK3和FRS评分≥10.0%，则CVD风险为高风险；如果QRISK3和FRS评分≥10.0%，则为低风险。结果：在T1D患者中，17.3%的患者QRISK3评分高，19.0%的患者FRS评分高。T2D患者中，31.9%的人QRISK3评分较高，37.2%的人FRS评分较高。结论：QRISK和FRS都是该人群心血管疾病的良好预测指标。年轻发病的糖尿病患者在10年内发生心血管疾病的倾向很高，其中T2D的风险高于T1D。对于年轻发病的T2D和T1D患者而言，定期进行风险监测、改变生活方式和医疗干预至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”