Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-02-13 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1507059

María E Santana-Román, Santos Ramírez-Carreto, Paola Maycotte, Victoria Pando-Robles

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Abstract

Arthropods serve as vectors for numerous arboviruses responsible for diseases worldwide. Despite their medical, veterinary, and economic significance, the interaction between arboviruses and arthropods remains poorly understood. Mitochondria in arthropods play a crucial role by supplying energy for cell survival and viral replication. Some arboviruses can replicate within arthropod vectors without harming the host. Successful transmission depends on efficient viral replication in the vector's tissues, ultimately reaching the salivary glands for transmission to a vertebrate host, including humans, via blood-feeding. This review summarizes current knowledge of mitochondrial function in arthropods during arbovirus infection, highlighting gaps compared to studies in mammals and other pathogens relevant to arthropods. It emphasizes mitochondrial processes in insects that require further investigation to uncover the mechanisms underlying arthropod-borne transmission.

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.