Methamphetamine and traumatic brain injury outcomes: an analysis of 29,416 patients from the national trauma data bank.

IF 1.5 4区医学 Q4 NEUROSCIENCES

Brain injury Pub Date : 2025-02-27 DOI:10.1080/02699052.2025.2469705

Nicholas W Sheets, Yan Shen, Jeneva M Garland, David S Plurad, Lori F Harbour, Alessandro Orlando, Samir M Fakhry

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引用次数: 0

Abstract

Background: Methamphetamine (Meth) use is rising in the US. Most research focuses on severe TBI, neglecting milder cases. We evaluated Meth's impact on patient outcomes and hospital resource use across all TBI severities.

Methods: This study included National Trauma Data Bank (NTDB) patients from 2017-2019, aged 18-54, with near-isolated TBI, a drug screen, and negative blood alcohol. Meth+ patients were compared to Meth- patients on demographics, injury severity, and outcomes using χ² and Wilcoxon rank-sum tests.

Results: Of 29,416 patients with TBI patients, 337 (1%) were Meth+. Meth+ patients had significantly higher ICU admissions (61% vs. 50%, p < 0.001), mechanical ventilation (32% vs. 22%, p < 0.001), and tracheostomy (7% vs. 4%, p < 0.008). Meth+ had longer hospital stays (median 4 vs. 3 days, p < 0.001) and higher cerebral monitor use (8% vs. 5%, p < 0.05). Mortality rates were similar (5% vs. 5%, p = 0.46). Meth+ patients had more preexisting mental health/personality (20% vs. 12%, p < 0.001) and substance use disorders (44% vs. 6%, p < 0.001).

Conclusions: Meth use in patients with near-isolated TBI patients is linked to greater injury severity, increased resource use, and longer hospital stays but does not significantly impact mortality. Targeted interventions are needed to manage clinical challenges and optimize resource utilization.

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甲基苯丙胺和创伤性脑损伤结果：来自国家创伤数据库的29,416例患者的分析。

背景：甲基苯丙胺（冰毒）的使用在美国正在上升。大多数研究都集中在严重的创伤性脑损伤上，而忽视了较轻的病例。我们评估了甲基苯丙胺对所有严重创伤性脑损伤患者预后和医院资源使用的影响。方法：本研究纳入2017-2019年国家创伤数据库（NTDB）患者，年龄18-54岁，近孤立性TBI，药物筛查，血液酒精阴性。使用χ 2和Wilcoxon秩和检验比较冰毒+患者和冰毒患者在人口统计学、损伤严重程度和结局方面的差异。结果：29,416例TBI患者中，337例（1%）为甲基安非他明+。甲安非他明+患者的ICU入院率显著高于甲安非他明+患者（61%比50%，p p p p p = 0.46）。甲基苯丙胺+患者有更多的先前存在的精神健康/人格（20% vs. 12%, p . p .）结论：甲基苯丙胺+患者在近孤立性TBI患者中使用与更严重的损伤、更多的资源使用和更长的住院时间有关，但对死亡率没有显著影响。需要有针对性的干预措施来管理临床挑战和优化资源利用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.