Risk Warning of Neutrophil-to-Lymphocyte Ratio for Neurological Recovery in Acute Ischemic Stroke After Thrombolysis: A Retrospective Study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-02-28 DOI:10.1002/brb3.70373

Yiran Zhao, Xu Wang, Wenxiu Qin, Shaojing Shi, Min Wang, Jinsheng Zhang, Xin Zou, Junfeng Xu, Jing Li, Xuemin Shi

{"title":"Risk Warning of Neutrophil-to-Lymphocyte Ratio for Neurological Recovery in Acute Ischemic Stroke After Thrombolysis: A Retrospective Study","authors":"Yiran Zhao, Xu Wang, Wenxiu Qin, Shaojing Shi, Min Wang, Jinsheng Zhang, Xin Zou, Junfeng Xu, Jing Li, Xuemin Shi","doi":"10.1002/brb3.70373","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To investigate the relationship between dynamic changes in the neutrophil-to-lymphocyte ratio (NLR) and neurological recovery in noninfected patients with acute cerebral infarction after thrombolysis.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective analysis was conducted on 277 patients with stroke thrombolysis. Least absolute shrinkage and selection operator (LASSO) regression was used to identify factors influencing recovery, and 1:1 propensity matching was performed between the groups to compare the changes in the National Institutes of Health Stroke Scale (NIHSS) score, muscle strength, and NLR after treatment. The receiver operating characteristic (ROC) curve was used to determine the cutoff value of NLR reduction after treatment, which serves as a diagnostic criterion for neurologic recovery. The posttreatment NLR reduction values were categorized according to whether they were equal to and greater than the cutoff value. Logistic regression was performed after intergroup matching to analyze the relationship between NLR and NIHSS.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The LASSO regression suggests that increased disease duration and atrial fibrillation are risk factors for neurologic recovery, whereas prolonged treatment duration and increased NLR reduction value are protective factors. Compared with the low-efficacy group, the high-efficacy group exhibited significantly lower NIHSS scores, NLR, and upper and lower extremity muscle strength scores after treatment (<i>p</i> < 0.05). The NLR reduction value was positively correlated with the NIHSS score reduction value and the change in the NIHSS score reduction rate (<i>p</i> < 0.001). The ROC curve and logistic regression indicated that patients with an NLR reduction value of ≥ 0.335 had good recovery.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Higher NLR reduction values indicate an improved neurologic prognosis after treatment.</p>\n </section>\n \n <section>\n \n <h3> Trial registration</h3>\n \n <p>Clinical Retrospectively Registered Trials: ChiCTR2100045415</p>\n </section>\n </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70373","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Behavior","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70373","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

To investigate the relationship between dynamic changes in the neutrophil-to-lymphocyte ratio (NLR) and neurological recovery in noninfected patients with acute cerebral infarction after thrombolysis.

Methods

A retrospective analysis was conducted on 277 patients with stroke thrombolysis. Least absolute shrinkage and selection operator (LASSO) regression was used to identify factors influencing recovery, and 1:1 propensity matching was performed between the groups to compare the changes in the National Institutes of Health Stroke Scale (NIHSS) score, muscle strength, and NLR after treatment. The receiver operating characteristic (ROC) curve was used to determine the cutoff value of NLR reduction after treatment, which serves as a diagnostic criterion for neurologic recovery. The posttreatment NLR reduction values were categorized according to whether they were equal to and greater than the cutoff value. Logistic regression was performed after intergroup matching to analyze the relationship between NLR and NIHSS.

Results

The LASSO regression suggests that increased disease duration and atrial fibrillation are risk factors for neurologic recovery, whereas prolonged treatment duration and increased NLR reduction value are protective factors. Compared with the low-efficacy group, the high-efficacy group exhibited significantly lower NIHSS scores, NLR, and upper and lower extremity muscle strength scores after treatment (p < 0.05). The NLR reduction value was positively correlated with the NIHSS score reduction value and the change in the NIHSS score reduction rate (p < 0.001). The ROC curve and logistic regression indicated that patients with an NLR reduction value of ≥ 0.335 had good recovery.

Conclusions

Higher NLR reduction values indicate an improved neurologic prognosis after treatment.

Trial registration

Clinical Retrospectively Registered Trials: ChiCTR2100045415

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

期刊介绍： Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)