Poor glycemic status as a risk factor for dementia in type 2 diabetes population: Findings from the Taiwan’s National Health Insurance Database

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-02-26 DOI:10.1016/j.diabres.2025.112065

Chia-Ling Lin , Wu-Chien Chien , Chun-Ping Lin , Chi-Hsiang Chung , Fei-Ling Wu

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引用次数: 0

Abstract

Aim

This study explored the association between poor glycemic status (PGS; hyperglycemia, hypoglycemia, or their combination [mixed]) and dementia risk in patients with type 2 diabetes (T2D).

Methods

In this retrospective cohort study, we conducted a secondary analysis using data from Taiwan’s National Health Insurance Database spanning the years 2000 to 2015. We employed propensity score matching (1:1) based on sex, age, index year, and inclusion date to select a comparison cohort, the Cox proportional-hazards regression analysis was performed to assess the effect of PGS on the risk of dementia. Kaplan–Meier survival analysis was performed to compare the cumulative incidence of dementia between patients with T2D and PGS and those without PGS.

Results

Among 192,977 patients with T2D, 57,893 had PGS during the follow-up period. Of them, 4,342 patients (7.5 %) developed dementia. PGS status was positively associated with dementia risk (adjusted hazard ratio: 2.01; 95 % confidence interval [CI]: 1.58–2.68). The risks of dementia were 1.56 (95 % CI: 1.22–2.08) for hypoglycemia, 1.64 (95 % CI: 1.30–2.18) for hyperglycemia, and 3.10 (95 % CI: 2.48–4.12) for mixed PGS.

Conclusions

In patients with T2D, PGS is associated with an increased risk of dementia, particularly in those experiencing significant fluctuations in glycemic levels.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.