Analysis of genes implicated in non-obstructive azoospermia

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-02-26 DOI:10.1016/j.steroids.2025.109583

Junwei Wang , Shuhui Wang , Meng Wang , Jinfei Yang

引用次数: 0

Abstract

Non-obstructive azoospermia (NOA) is the most common cause of male infertility, accounting for approximately 60 % of azoospermia cases. In recent years, gene mutations have emerged as the primary factor under investigation for the etiology of NOA. Therefore, finding the cause and pathogenesis of NOA at the genetic level has become one of the current research hotspots. Genetic analysis of NOA patients revealed that gene mutations primarily concentrate in protein-coding regions and non-coding RNAs, predominantly occurring in cases of non-obstructive azoospermia. Hence, understanding the relationship between these gene mutations and NOA can not only provide new ideas for treatment, but also provide a theoretical basis for revealing the pathogenesis of NOA. This article comprehensively reviews recent advancements in identifying genes that are intricately associated with azoospermia. These results will provide meaningful guidance for the future development of NOA-targeted therapeutic drugs.

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与非阻塞性无精子症相关的基因分析

非阻塞性无精子症（NOA）是男性不育的最常见原因，约占无精子症病例的60%。近年来，基因突变已成为NOA病因研究的主要因素。因此，在遗传水平上寻找NOA的病因和发病机制已成为当前的研究热点之一。NOA患者的遗传分析显示，基因突变主要集中在蛋白质编码区和非编码rna中，主要发生在非阻塞性无精子症病例中。因此，了解这些基因突变与NOA之间的关系不仅可以为治疗提供新的思路，而且可以为揭示NOA的发病机制提供理论依据。本文全面回顾了在鉴定与无精子症复杂相关的基因方面的最新进展。这些结果将为今后开发靶向noa治疗药物提供有意义的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.