57. Intralesional Cidofovir: A Promising Treatment for Refractory Genital Warts in Pediatric Patients

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Mónica Muñoz , Carolina Pastene , Jorge Morales , Patricio Garcia , eugenio Ramirez , Nicole Bruneau , monserrat Balanda , Paula Muñoz , Magdalena Castro , Patricia Romero
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引用次数: 0

Abstract

Background

Human Papillomavirus (HPV) infections can lead to genital warts (GW) in pediatric patients, posing significant treatment challenges. Currently, no FDA-approved therapies for GW exist for children under 12, and conventional treatments often result in high recurrence rates. Emerging evidence suggests that intralesional Cidofovir, a broad-spectrum antiviral, may be effective for refractory GW, as demonstrated in related conditions like recurrent laryngeal papillomatosis.

Case

We present a case of a 2-year-and-8-month-old girl with persistent GW, unresponsive to multiple treatment regimens, including podophyllotoxin, liquid nitrogen, imiquimod, and trichloroacetic acid. After 2 years of failed therapies and a persistent HPV genotype 11 infection, she underwent surgical excision with intralesional Cidofovir instillation. Two years post-treatment, the patient remained asymptomatic, with no recurrence of vulvar lesions, and a negative HPV PCR molecular test. Ethics Approval: This case was reviewed and approved by the Ethics Committee of Hospital Dr. Luis Calvo Mackenna, in accordance with institutional guidelines.

Comments

This case underscores the potential of intralesional Cidofovir as a promising treatment for refractory GW in pediatric patients. Given the lack of approved therapies for children and the high recurrence rates associated with conventional treatments, Cidofovir may offer a new therapeutic option. Further studies are necessary to explore its efficacy as a first-line treatment for this vulnerable population. Financial Disclosure: The authors have no financial relationships relevant to this case to disclose.
57. 西多福韦:一种有希望治疗顽固性生殖器疣的儿科患者
背景:人乳头瘤病毒(HPV)感染可导致儿科患者生殖器疣(GW),给治疗带来重大挑战。目前,fda还没有批准用于12岁以下儿童的GW治疗方法,传统治疗方法往往导致高复发率。新出现的证据表明,病变内西多福韦是一种广谱抗病毒药物,可能对难治性GW有效,如复发性喉乳头状瘤病。我们报告了一个2岁零8个月大的女孩,患有持续性GW,对多种治疗方案无反应,包括鬼臼毒素、液氮、咪喹莫特和三氯乙酸。经过2年的治疗失败和持续的HPV基因型11感染后,她接受了手术切除和病灶内注射西多福韦。治疗两年后,患者无症状,无外阴病变复发,HPV PCR分子检测阴性。伦理批准:本病例由Luis Calvo Mackenna医生的医院伦理委员会根据机构指南进行审查和批准。该病例强调了西多福韦作为难治性GW患儿的治疗方法的潜力。鉴于缺乏批准的儿童治疗方法以及与传统治疗相关的高复发率,西多福韦可能提供一种新的治疗选择。需要进一步的研究来探索其作为这一弱势群体的一线治疗方法的有效性。财务披露:作者没有与本案例相关的财务关系需要披露。
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来源期刊
CiteScore
3.90
自引率
11.10%
发文量
251
审稿时长
57 days
期刊介绍: Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.
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