Assessment of Tunisian clays for their potential application as excipient in pharmaceutical preparations: 2-amino-5-chlorobenzophenone adsorption

IF 5.3 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2025-03-01 DOI:10.1016/j.clay.2025.107760

Safa Gamoudi , Jihene Manai , Wilfried G. Kanhounnon , Didilia Ileana Mendoza-Castillo , Adrián Bonilla-Petriciolet , Yann Foucaud , George E. Christidis , Ezzeddine Srasra , Michael Badawi

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引用次数: 0

Abstract

The objective of this manuscript was to test the drug-loading and delivery properties of Tunisian clays to demonstrate their potential as low-cost excipients in pharmaceutical formulations. Raw kaolinite, purified smectite, and organophilic smectite were studied for the adsorption and desorption of 2-amino-5-chlorobenzophenone (2A-5BC) as a drug model molecule. The adsorption and desorption properties of these clay samples were investigated under different pH conditions, including those emulating the intestinal and gastric fluids from human body. DFT calculations were performed to characterize the atomic interactions involved in the adsorption mechanism. The adsorption and desorption properties of these clays were correlated with their main physicochemical properties and textural parameters. The maximum 2A-5BC adsorption (i.e., 48.2 mg/g) was achieved using smectite functionalized with HDTMA. Electrostatic forces and hydrogen bonds played a relevant role during 2A-5BC adsorption. The desorption of 2A-5BC from clay samples was effective at 37 °C and pH similar to the intestinal and gastric fluids, thus reaching desorption efficiencies of up to 93 %. 2A-5BC desorption data were modeled with the Korsmeyer-Peppas equation and the results indicated the presence of a non-Fickian mass transport. Tunisian smectite functionalized with HDTMA presented promising performance and can be considered as a potential excipient in pharmaceutical formulations.

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...