Assessment of Tunisian clays for their potential application as excipient in pharmaceutical preparations: 2-amino-5-chlorobenzophenone adsorption

IF 5.3 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2025-03-01 DOI:10.1016/j.clay.2025.107760

Safa Gamoudi , Jihene Manai , Wilfried G. Kanhounnon , Didilia Ileana Mendoza-Castillo , Adrián Bonilla-Petriciolet , Yann Foucaud , George E. Christidis , Ezzeddine Srasra , Michael Badawi

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引用次数: 0

Abstract

The objective of this manuscript was to test the drug-loading and delivery properties of Tunisian clays to demonstrate their potential as low-cost excipients in pharmaceutical formulations. Raw kaolinite, purified smectite, and organophilic smectite were studied for the adsorption and desorption of 2-amino-5-chlorobenzophenone (2A-5BC) as a drug model molecule. The adsorption and desorption properties of these clay samples were investigated under different pH conditions, including those emulating the intestinal and gastric fluids from human body. DFT calculations were performed to characterize the atomic interactions involved in the adsorption mechanism. The adsorption and desorption properties of these clays were correlated with their main physicochemical properties and textural parameters. The maximum 2A-5BC adsorption (i.e., 48.2 mg/g) was achieved using smectite functionalized with HDTMA. Electrostatic forces and hydrogen bonds played a relevant role during 2A-5BC adsorption. The desorption of 2A-5BC from clay samples was effective at 37 °C and pH similar to the intestinal and gastric fluids, thus reaching desorption efficiencies of up to 93 %. 2A-5BC desorption data were modeled with the Korsmeyer-Peppas equation and the results indicated the presence of a non-Fickian mass transport. Tunisian smectite functionalized with HDTMA presented promising performance and can be considered as a potential excipient in pharmaceutical formulations.

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突尼斯粘土作为药物制剂辅料的潜在应用评价：2-氨基-5-氯苯甲酮的吸附

本文的目的是测试突尼斯粘土的载药和输送特性，以证明它们作为药物配方中低成本赋形剂的潜力。研究了生高岭石、纯化蒙脱石和亲有机蒙脱石对2-氨基-5-氯苯甲酮（2A-5BC）的吸附解吸作用。研究了这些粘土样品在不同pH条件下的吸附和解吸性能，包括模拟人体肠道和胃液的pH条件。DFT计算表征了吸附机理中涉及的原子相互作用。这些粘土的吸附和解吸性能与其主要理化性质和结构参数有关。用HDTMA功能化的蒙脱石可达到最大的2A-5BC吸附量（即48.2 mg/g）。静电力和氢键在2A-5BC吸附过程中发挥了相关作用。粘土样品的2A-5BC在37°C和pH值与肠道和胃液相似的条件下有效解吸，因此解吸效率高达93%。用Korsmeyer-Peppas方程对2A-5BC解吸数据进行了建模，结果表明存在非菲克式质量输运。突尼斯蒙脱石经HDTMA功能化后表现出良好的性能，可作为一种潜在的赋形剂应用于医药制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...