CuI-Catalyzed Dearomatization/Peroxidation/Cyclization Cascade of Pyrrole-Tethered Indoles

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-02-27 DOI:10.1021/acs.joc.4c02977

Xue Sheng, Liu Yang, Jia-Yi Han, Xin Yu, Hai-Lei Cui

引用次数: 0

Abstract

A mild CuI-catalyzed dearomatization/peroxidation/cyclization cascade of pyrrole-tethered indoles has been reached, providing peroxide-incorporated indolizino[8,7-b]indole derivatives in acceptable to good yields (46–76%). Dehydrogenated peroxide can be obtained by the use of a FeCl₃/TBHP (tBuOOH)/2,2,2-trifluoroethanol (TFE) system at 50 °C.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.