Barrier and protective effects of a newly developed medical device for the treatment of gastroesophageal reflux disease.

IF 1.9 Q3 GASTROENTEROLOGY & HEPATOLOGY
Federico Benetti, Elisa Gaio, Stefano Agostini
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Abstract

Background: Gastroesophageal reflux disease is a clinical condition due to the reflux of stomach contents and leading either to erosive or non-erosive disease. Repeated exposure of esophagus to hydrochloric acid, pepsin, bile salts and pancreatic enzymes in gastric contents damages esophageal mucosa, causing inflammation and increased paracellular permeability. A possible therapy for gastroesophageal reflux disease should hinder gastroesophageal reflux and provide esophageal mucosal protection against all aggressive components. The medical device (Med) tested in this study was developed for the treatment of gastroesophageal reflux disease with the aim to achieve a barrier to protect esophageal mucosa against reflux damages and neutralization of the acidic pocket in the stomach.

Methods: The efficacy of Med in forming a protective barrier was performed in vitro using a cellular model of reconstructed human oral epithelium, monitoring its ability to reduce the passage of substances once the formulation was applied, as well as the subsequent reduction in inflammation and toxic effects after exposure to the Triton X-100 stimulus.

Results: The medical device is able of creating an effective barrier at the level of epithelial cells. Its protective action is demonstrated by the ability in reducing toxicity and inflammation induced by an irritant agent.

Conclusions: This work shows the promising effects of Med as a therapeutic solution for managing signs and symptoms associated with gastroesophageal reflux, capable of exerting its function through a physical action without compromising the physiological balance of epithelial cells.

一种新开发的治疗胃食管反流病的医疗装置的屏障和保护作用。
背景:胃食管反流病是胃内容物反流引起的一种临床疾病,可导致糜烂性或非糜烂性疾病。食管反复暴露于胃内容物中的盐酸、胃蛋白酶、胆盐和胰酶,可损伤食管黏膜,引起炎症并增加细胞旁通透性。一种可能的治疗胃食管反流病的方法应该是阻止胃食管反流,并提供食管黏膜保护以抵抗所有侵袭性成分。本研究中测试的医疗装置(Med)是为治疗胃食管反流病而开发的,目的是实现一个屏障,保护食管黏膜免受反流损害,中和胃中的酸性口袋。方法:利用体外重建的人口腔上皮细胞模型,观察Med在体外形成保护屏障的功效,监测其在使用该制剂后减少物质通过的能力,以及暴露于Triton X-100刺激后炎症和毒性作用的减少。结果:该医疗装置能够在上皮细胞水平上形成有效的屏障。它的保护作用是通过减少刺激剂引起的毒性和炎症的能力来证明的。结论:这项工作表明,Med作为一种治疗胃食管反流相关症状和体征的有希望的效果,能够通过物理作用发挥其功能,而不损害上皮细胞的生理平衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
3.10
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