Association of different folate statuses with sleep disturbances in adults in the US: Data from NHANES 2007-2016.

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Sleep Health Pub Date : 2025-02-25 DOI:10.1016/j.sleh.2025.01.005

Jiayuan Tu, Xiaoqiao Mo, Zihao Chen, Lijuan Xi, Chunhui Wu, Tian Xie, Yongzhuang Chen

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引用次数: 0

Abstract

Objective: To explore the associations between three folate statuses (folate intake, serum folate, and red blood cell folate) and sleep disturbances in adults.

Methods: Trends in sleep disturbances in five consecutive cycles were evaluated using Cochran-Armitage tests. Survey-weighted logistic regression models, restricted cubic spline models, and interaction analysis were used to evaluate the associations between different statuses of folate and sleep disturbances.

Results: This cross-sectional study included 20,200 eligible adults from five cycles of NHANES (2007-2016). The overall crude prevalence of sleep disturbances increased over time from 25.8% (95% confidence intervals, 23.6%, 28.0%) in 2007-2008 to 29.3% (95% confidence intervals, 25.9%, 32.9%) in 2015-2016 (P for trend <.001). In adjusted, weighted multivariable regression models, compared to the second quartile (Q2), lower folate intake levels (Q1, odds ratio=1.22, 95% confidence intervals: 1.06, 1.40), higher folate intake levels (Q4, odds ratio=1.18, 95% confidence intervals: 1.01, 1.38), and higher red blood cell folate levels (Q4, odds ratio=1.17, 95% confidence intervals: 1.03, 1.33) were independently associated with higher odds of sleep disturbances. The restricted cubic spline models revealed U-shaped, nonlinear associations between different folate statuses and the risk of sleep disturbances. A daily folate intake of approximately 439 mcg, a serum folate concentration of approximately 35nom/L, and an red blood cell folate concentration of approximately 886nmol/L were associated with the lowest risk of sleep disturbances. The results were robust in interaction and sensitivity analyses.

Conclusions: We observed U-shaped associations between folate intake, serum folate, red blood cell folate, and sleep disturbances among US adults.

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来源期刊

Sleep Health CLINICAL NEUROLOGY-

CiteScore

6.30

自引率

9.80%

发文量

114

审稿时长

54 days

期刊介绍： Sleep Health Journal of the National Sleep Foundation is a multidisciplinary journal that explores sleep''s role in population health and elucidates the social science perspective on sleep and health. Aligned with the National Sleep Foundation''s global authoritative, evidence-based voice for sleep health, the journal serves as the foremost publication for manuscripts that advance the sleep health of all members of society.The scope of the journal extends across diverse sleep-related fields, including anthropology, education, health services research, human development, international health, law, mental health, nursing, nutrition, psychology, public health, public policy, fatigue management, transportation, social work, and sociology. The journal welcomes original research articles, review articles, brief reports, special articles, letters to the editor, editorials, and commentaries.