Maternal smoking and its short- or long-term impact on offspring liver pathologies: a review of experimental and clinical studies.

IF 1.6 4区医学 Q4 TOXICOLOGY

Toxicological Research Pub Date : 2024-12-21 eCollection Date: 2025-03-01 DOI:10.1007/s43188-024-00271-y

Daram Yang, Yu Ji Kim, Jong-Won Kim

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引用次数: 0

Abstract

This review investigates the correlation between prenatal tobacco exposure and the risk of liver diseases in offspring. By synthesizing data from clinical trials and animal studies, it provides a comprehensive overview of the potential mechanisms underlying this association. This review begins by analyzing the prevalence of maternal smoking and its impact on fetal development. It then discusses specific liver diseases observed in offspring exposed prenatally to tobacco, such as acute liver injuries and metabolic dysfunction-associated fatty liver disease, and discusses the underlying pathophysiological pathways. Current evidence indicates that altered fetal liver development, oxidative stress, and genetic modifications may predispose offspring to liver diseases. Furthermore, this review highlights the gaps in current research and the need for longitudinal studies to better understand the long-term effects of prenatal tobacco exposure on the liver. The review concludes with recommendations for public health policies aimed at enhancing our understanding of maternal smoking and mitigating its adverse effects on offspring, emphasizing the importance of smoking cessation during pregnancy.

Graphical abstract:

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母亲吸烟及其对后代肝脏病理的短期或长期影响：实验和临床研究综述。

本文综述了产前烟草暴露与后代肝脏疾病风险之间的关系。通过综合临床试验和动物研究的数据，它提供了这种关联的潜在机制的全面概述。本综述首先分析了孕产妇吸烟的患病率及其对胎儿发育的影响。然后讨论了在产前暴露于烟草的后代中观察到的特定肝脏疾病，如急性肝损伤和代谢功能障碍相关的脂肪肝疾病，并讨论了潜在的病理生理途径。目前的证据表明，胎儿肝脏发育改变、氧化应激和基因修饰可能使后代易患肝脏疾病。此外，这篇综述强调了目前研究的差距和纵向研究的必要性，以更好地了解产前烟草暴露对肝脏的长期影响。该审查最后提出了公共卫生政策建议，旨在加强我们对孕产妇吸烟的了解，减轻其对后代的不利影响，强调怀孕期间戒烟的重要性。图形化的简介:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicological Research TOXICOLOGY-

CiteScore

4.20

自引率

4.30%

发文量

期刊介绍： Toxicological Research is the official journal of the Korean Society of Toxicology. The journal covers all areas of Toxicological Research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. The journal’s mission is to disseminate scientific and technical information on diverse areas of toxicological research. Contributions by toxicologists, molecular biologists, geneticists, biochemists, pharmacologists, clinical researchers and epidemiologists with a global view on public health through toxicological research are welcome. Emphasis will be given to articles providing an understanding of the toxicological mechanisms affecting animal, human and public health. In the case of research articles using natural extracts, detailed information with respect to the origin, extraction method, chemical profiles, and characterization of standard compounds to ensure the reproducible pharmacological activity should be provided.