Xin Xue, Kun Qian, Li-Bo Zhao, Wei-Hao Xu, Ying-Hui Gao, Zhe Zhao, Wei-Meng Cai, Tian-Jiao Li, Ting-Yu Nie, Dong Rui, Shao-Hua Chen, Yao Ma, Jun-Ling Lin, Xiao-Shun Qian, Lin Liu
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引用次数: 0
Abstract
Background: The rising rates of obstructive sleep apnea (OSA) and frailty among older adults are linked to higher mortality rates. Depression merges as a critical determinant associated with both OSA and frailty. This study investigates the impact of depression on the risk of developing frailty in older adults diagnosed with OSA.
Method: Data from 1,021 older adults diagnosed with OSA were analyzed. Participants were stratified into two groups based on their scores on the 12-item Geriatric Depression Scale (GDS-12) to evaluate differences in frailty incidence over time.
Result: Depression was identified in 113 patients (11.0%). Frailty developed in 276 patients during the median 52-month follow-up. The multivariate analysis indicated a significant link between depression and increased frailty risk (aHR = 2.65; 95% CI: 2.01-3.05; P < 0.001). Further subgroup analyses indicated that patients with moderate-to-severe OSA (aHR = 3.01; 95% CI: 2.20-4.10; P < 0.001) who also experienced depression faced a particularly heightened risk of frailty.
Conclusion: Depression is prevalent among older adults with OSA and constitutes an independent risk factor for frailty development. These findings underscore the need for targeted interventions addressing depression in this population to mitigate frailty risk.
期刊介绍：
The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep.
Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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