The new perspective of gasotransmitters in cancer metastasis

IF 3.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yu-Bo Shi , Lin Cheng , Yue Lyu , Ze-Jing Shi
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引用次数: 0

Abstract

Cancer metastasis is the leading cause of death in cancer patients, which renders heavy burdens to family and society. Cancer metastasis is a complicated process in which a large variety of biological molecules, cells and signaling pathways are involved. Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are common air pollutants which are harmful to human bodies and environments. However, recent studies show that these gases, which are collectively termed gasotransmitters, play significant roles in physiological homeostasis and pathogenesis including immunological responses, neuronal regulations, respiratory as well as cardiovascular diseases, metabolic disorders and cancers. These gases are abnormally expressed in cancer cells or tissues, along with the gas-producing enzymes. They have been demonstrated to participate in cancer metastasis intensively by modulating diverse signaling axes. This review introduces the nature of gasotransmitters, summaries novel research progression in gasotransmitters-induced cancer metastasis and elucidates multifaceted mechanisms how the process is modulated, with an effort to bring new therapeutic targets for cancer management in the future.
气体递质在肿瘤转移中的新视角。
癌症转移是癌症患者死亡的主要原因,给家庭和社会带来了沉重的负担。肿瘤转移是一个复杂的过程,涉及多种生物分子、细胞和信号通路。一氧化氮(NO)、一氧化碳(CO)和硫化氢(H2S)是常见的对人体和环境有害的空气污染物。然而,最近的研究表明,这些气体(统称为气体递质)在生理稳态和发病机制中发挥重要作用,包括免疫反应、神经元调节、呼吸系统疾病、心血管疾病、代谢紊乱和癌症。这些气体与产气酶一起在癌细胞或组织中异常表达。它们已被证明通过调节多种信号轴强烈参与癌症转移。本文介绍了气体递质的性质,综述了气体递质诱导肿瘤转移的最新研究进展,并从多方面阐述了气体递质诱导肿瘤转移的调控机制,以期为今后的肿瘤治疗提供新的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nitric oxide : biology and chemistry
Nitric oxide : biology and chemistry 生物-生化与分子生物学
CiteScore
7.50
自引率
7.70%
发文量
74
审稿时长
52 days
期刊介绍: Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.
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