The new perspective of gasotransmitters in cancer metastasis

Abstract

Cancer metastasis is the leading cause of death in cancer patients, which renders heavy burdens to family and society. Cancer metastasis is a complicated process in which a large variety of biological molecules, cells and signaling pathways are involved. Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H₂S) are common air pollutants which are harmful to human bodies and environments. However, recent studies show that these gases, which are collectively termed gasotransmitters, play significant roles in physiological homeostasis and pathogenesis including immunological responses, neuronal regulations, respiratory as well as cardiovascular diseases, metabolic disorders and cancers. These gases are abnormally expressed in cancer cells or tissues, along with the gas-producing enzymes. They have been demonstrated to participate in cancer metastasis intensively by modulating diverse signaling axes. This review introduces the nature of gasotransmitters, summaries novel research progression in gasotransmitters-induced cancer metastasis and elucidates multifaceted mechanisms how the process is modulated, with an effort to bring new therapeutic targets for cancer management in the future.