Novel Role of Microtubule-Associated Serine/Threonine Kinase Like as a Good Prognostic Factor in Oral Squamous Cell Carcinoma and Evidences for a Link with Smad7.

IF 3.5 4区医学 Q3 CELL BIOLOGY

Pathobiology Pub Date : 2025-02-26 DOI:10.1159/000544183

Esperanza Pozo-Agundo, Miguel Álvarez-González, Paloma Lequerica-Fernández, Sergi Herrera I Nogués, Juan Pablo Rodrigo, Tania Rodríguez-Santamarta, Héctor E Torres-Rivas, Saúl Álvarez-Teijeiro, Juana María García-Pedrero, Mónica Álvarez-Fernández, Juan Carlos de Vicente

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引用次数: 0

Abstract

Introduction: Upregulated microtubule-associated serine/threonine kinase like (MASTL), a cell cycle kinase required for a progression through mitosis, expression has been associated to poor prognosis. This study aimed to investigate the clinical relevance of MASTL expression in oral squamous cell carcinoma (OSCC) and a possible mechanistic link with epithelial-mesenchymal transition (EMT).

Methods: Immunohistochemical analysis of MASTL, E-cadherin, vimentin, and Smad7 was performed in paraffin-embedded tissue specimens from 148 OSCC patients.

Results: Nuclear MASTL expression was detected in 115 (77.7%) OSCC specimens. High MASTL expression was significantly associated with the male gender, smoking habit, T stage, early clinical stage, and absence of vascular invasion. MASTL expression was inversely correlated with Smad7, whereas no association was observed with E-cadherin and vimentin. Patients harboring tumors with low MASTL expression exhibited a poorer overall survival. Smad7 expression was significantly related to reduced disease-specific and overall survival. High levels of MASTL expression were associated with better prognosis in T3 patients, N0 cases, and patients treated by surgery combined with radiotherapy and chemotherapy.

Conclusion: The present study uncovers MASTL as a good prognostic factor in OSCC and a potential link with EMT via Smad7.

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微管相关丝氨酸/苏氨酸激酶样（MASTL）在口腔鳞状细胞癌中作为良好预后因素的新作用以及与Smad7相关的证据

微管相关丝氨酸/苏氨酸激酶样（MASTL）是一种细胞周期激酶，是有丝分裂进程所必需的，其表达上调与预后不良有关。本研究旨在探讨MASTL在口腔鳞状细胞癌（OSCC）中表达的临床意义，以及与上皮-间质转化（EMT）的可能机制联系。方法：对148例OSCC患者石蜡包埋组织标本进行MASTL、E-cadherin、Vimentin、Smad7的免疫组化分析。结果：115例（77.7%）OSCC标本中检测到核MASTL表达。MASTL高表达与男性、吸烟习惯、T分期、早期临床分期、无血管侵犯相关。MASTL的表达与Smad7呈负相关，而与E-cadherin和Vimentin无相关性。具有低MASTL表达的肿瘤的患者表现出较差的总生存率。Smad7的表达与疾病特异性和总生存率的降低显著相关。T3患者、0例患者和手术加放化疗患者中，MASTL高表达与预后较好相关。结论：本研究发现MASTL是OSCC的一个良好预后因素，并通过Smad7与EMT有潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathobiology 医学-病理学

CiteScore

8.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.