Novel Role of Microtubule-Associated Serine/Threonine Kinase Like as a Good Prognostic Factor in Oral Squamous Cell Carcinoma and Evidences for a Link with Smad7.
Esperanza Pozo-Agundo, Miguel Álvarez-González, Paloma Lequerica-Fernández, Sergi Herrera I Nogués, Juan Pablo Rodrigo, Tania Rodríguez-Santamarta, Héctor E Torres-Rivas, Saúl Álvarez-Teijeiro, Juana María García-Pedrero, Mónica Álvarez-Fernández, Juan Carlos de Vicente
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引用次数: 0
Abstract
Introduction: Upregulated microtubule-associated serine/threonine kinase like (MASTL), a cell cycle kinase required for a progression through mitosis, expression has been associated to poor prognosis. This study aimed to investigate the clinical relevance of MASTL expression in oral squamous cell carcinoma (OSCC) and a possible mechanistic link with epithelial-mesenchymal transition (EMT).
Methods: Immunohistochemical analysis of MASTL, E-cadherin, vimentin, and Smad7 was performed in paraffin-embedded tissue specimens from 148 OSCC patients.
Results: Nuclear MASTL expression was detected in 115 (77.7%) OSCC specimens. High MASTL expression was significantly associated with the male gender, smoking habit, T stage, early clinical stage, and absence of vascular invasion. MASTL expression was inversely correlated with Smad7, whereas no association was observed with E-cadherin and vimentin. Patients harboring tumors with low MASTL expression exhibited a poorer overall survival. Smad7 expression was significantly related to reduced disease-specific and overall survival. High levels of MASTL expression were associated with better prognosis in T3 patients, N0 cases, and patients treated by surgery combined with radiotherapy and chemotherapy.
Conclusion: The present study uncovers MASTL as a good prognostic factor in OSCC and a potential link with EMT via Smad7.
期刊介绍：
''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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